Browsing by Author "Ciccarelli, Michele"
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Dual role of grk5 in cancer development and progression
Gambardella, Jessica; Franco, Antonietta; Del Giudice, Carmine; Fiordelisi, Antonella; Cipolletta, Ersilia; Ciccarelli, Michele; Trimarco, Bruno; Iaccarino, Guido; Sorriento, Daniela (2016)GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the ... -
Larger blood pressure reduction by fixed-dose compared to free dose combination therapy of ace inhibitor and calcium antagonist in hypertensive patients
Visco, Valeria; Finelli, Rosa; Pascale, Antonietta Valeria; Giannotti, Rocco; Fabbricatore, Davide; Ragosa, Nicola; Ciccarelli, Michele; Iaccarino, Guido (2017)The introduction of fixed combination of ACEi+CCB (Fixed) has significantly increased patients compliance and adherence to therapy. At the moment, however, there are no data suggesting the better control of once-daily ... -
A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
Cipolletta, Ersilia; Ciccarelli, Michele; Izzo, Raffaele; Finelli, Rosa; Trimarco, Bruno; Iaccarino, Guido (2012)Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension ... -
Rays sting: the acute cellular effects of ionizing radiation exposure
Franco, Antonietta; Ciccarelli, Michele; Sorriento, Daniela; Napolitano, Luigi; Fiordelisi, Antonella; Trimarco, Bruno; Durante, Marco; Iaccarino, Guido (2016)High-precision radiation therapy is a clinical approach that uses the targeted delivery of ionizing radiation, and the subsequent formation of reactive oxygen species (ROS) in high proliferative, radiation sensitive cancers. ... -
Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization
Sorriento, Daniela; Ciccarelli, Michele; Santulli, Gaetano; Illario, Maddalena; Trimarco, Bruno; Iaccarino, Guido (2014)G protein coupled receptor kinase 2 (GRK2) has a key role in cellular function by regulating different intracellular mechanisms in a kinase dependent or independent manner. In this review we have dealt with the recently ...