Browsing by Subject "Epigenetic"
Now showing items 1-2 of 2
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Development of novel anticancer compounds directed towards promising therapeutic targets
(Universita degli studi di Salerno, 2023-04-19)Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this ... -
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(Universita degli studi di Salerno, 2021-06-25)Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...