Sfoglia per Autore "Campiglia, Pietro"
Items 1-11 di 11
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Analysis and evaluation of potential nutracentical milk and dairy products derived from the Centrale del latte di Salerno
Pepe, Giacomo (Universita degli studi di Salerno, 2015-03-16)The main objective of my PhD has been focused to the analysis and characterization of milk and dairy products derived from “Centrale del Latte di Salerno” in order to assess their potential use as dietary supplements and ... -
Characterization and biological properties of Citrus industrial derivatives and waste products for the formulation of nutraceuticals
Pagano, Francesco (Universita degli studi di Salerno, 2015-03-16)Polyphenols are natural chemical compounds, common in higher plants as and particularly known and appreciated for their health properties. We focused attention on Citrus bergamia, Citrus sinensis, Mela annurca and Vitis ... -
Design and synthesis of bioactive small molecules by traditional and innovative methods
Ciaglia, Tania (Universita degli studi di Salerno, 2018-03-28)My PhD research plan concerns the exploration of the structural requirements determining TRPM8 modulation. We prepared a series of N-substituted tryptamines and identified two compounds acting, respectively, as an activator ... -
Design and synthesis of modulators of apoptotic activity
Di Sarno, Veronica (Universita degli studi di Salerno, 2016-03-23)p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ... -
Design and synthesis of new integrase inhibitors
Spensiero, Antonia (Universita degli studi di Salerno, 2017-03-28)The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ... -
Design and synthesis of peptides involved in the inhibition of influenza virus infection
Scala, Maria Carmina (Universita degli studi di Salerno, 2017-03-28)The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ... -
Design and synthesis of peptides that modulate apoptotic process.
Vernieri, Ermelinda (Universita degli studi di Salerno, 2014-11-17)Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ... -
Design and synthesis of small molecules as ion channel modulators
Vestuto, Vincenzo (Universita degli studi di Salerno, 2022-05-02)My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of ... -
Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
Basilicata, Manuela Giovanna (Universita degli studi di Salerno, 2021-06-17)My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ... -
OC.2- A fluorescence-based assay to evaluate the activity of Kv7.2/Kv7.3 channel modulators
Nappi, Piera; Miceli, Francesco; Lauritano, Anna; Ostacolo, Carmine; Campiglia, Pietro; Taglialatela, Maurizio; Annual Meeting of the Neapolitan Brain Group 8. <2018 ; Naples> (2019) -
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
Salviati, Emanuela (Universita degli studi di Salerno, 2021-06-06)The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ...