Sfoglia per Soggetto "Epigenetics"
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Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(Universita degli studi di Salerno, 2016-04-20)The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ... -
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(Universita degli studi di Salerno, 2017-03-27)JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ... -
Functional Characterization of Candida albicans Hst3p histone deacetylase
(Universita degli studi di Salerno, 2019-05-07)The unicellular eukaryotic organism Candida albicans is one of the most important fungi in medicine, used as experimental model to study fungal pathologies and the underlying biology of dimorphic fungi. This fungus is a ... -
Integrated approach in Human Biomonitoring: epigenetic profile for environment-health study correlation
(Universita degli studi di Salerno, 2021-05-18)Human Biomonitoring (HB) represents a useful tool to investigate the complex relationship existing between environment and health. Assess human exposure to external stressors means to deepen observe, with a holistic ... -
Pilot study on epigenetic response to a mind-body treatment
(2017)In the last years, epigenetics and functional genomics methods to evaluate the genomic effects and mechanisms of mind-body therapies have increasingly grown. DNA microarray technology has been used to show the involvement ... -
Role of H3K56 acetylation in Candida albicans virulence
(Universita degli studi di Salerno, 2022-12-20)Candida spp., especially Candida albicans, represent the third most frequent cause of infection in Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal resistance drastically ...