Sfoglia per Autore "De Tommasi, Nunziatina"
Items 1-20 di 20
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Biophysical investigation of biomolecules in bio-membrane models
Di Marino, Sara (Universita degli studi di Salerno, 2012-05-30)Many drugs are available for the treatment of systemic or superficial mycoses, but only a limited number of them are effective antifungal drugs, devoid of toxic and undesirable side effects. Therefore there remains an ... -
Chemical proteomics on ligand protein
Margarucci, Luigi (Universita degli studi di Salerno, 2011-03-18)The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ... -
A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
Ambrosio, Letizia (Universita degli studi di Salerno, 2013-10-14) -
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
Prota, Lucia (Universita degli studi di Salerno, 2012-03-07)The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ... -
Design and synthesis of new polycyclic compounds with potential anticancer activity
Musella, Simona (Universita degli studi di Salerno, 2011-02-21)p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ... -
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
More, Vijaykumar (Universita degli studi di Salerno, 2014-05-21)The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters. The title of the thesis clearly reflects the ... -
Design and synthesis of “small molecules” as antiviral and radiotracer agents
Sellitto, Grazia (Universita degli studi di Salerno, 2011-03-28)The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ... -
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
Viviano, Monica (Universita degli studi di Salerno, 2013-04-03)The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ... -
Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases
Milite, Ciro (Universita degli studi di Salerno, 2011-02-21)The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ... -
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
De Simone, Rosa (Universita degli studi di Salerno, 2011-03-21)Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ... -
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
Chini, Maria Giovanna (Universita degli studi di Salerno, 2012-03-30)Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization. The study ... -
Development and Evaluation of Innovative Stationary Phases for Separation of Pharmaceuticals, Metabolites and Biocompounds
Grasso, Giuliana (Universita degli studi di Salerno, 2020-09-18)Biofluids are typical complex matrices representing a source of potential biomarkers, but often require high demands in sample preparation prior to analysis. With this purpose, several techniques have been developed ... -
Development of selective materials and methods for analytical techniques combined with mass spectrometry
Euterpio, Maria Anna (Universita degli studi di Salerno, 2015-04-23)Mass spectrometry (MS) is a powerful detection technique that has become very important in several chemical disciplines for detection of both small molecules (environmental pollutants, small metabolites) and large biomolecules ... -
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
Nuzzo, Genoveffa (Universita degli studi di Salerno, 2012-02-23)It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ... -
Molecular dynamics investigations of drug-cell membrane interactions
Campana, Federica (Universita degli studi di Salerno, 2013-04-22)The cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks. The complex dynamic structure of the plasma membrane ... -
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
Lauro, Gianluigi (Universita degli studi di Salerno, 2013-05-14)Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ... -
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
Pagano, Bruno (Universita degli studi di Salerno, 2011-10-06)Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple eliche in regioni ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
Pesca, Mariasabina (Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
Eletto, Daniela (Universita degli studi di Salerno, 2012-03-21)Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ... -
Target-based study to identify new bioactive diterpenes
Fiengo, Lorenzo (Universita degli studi di Salerno, 2019-04-16)Target identification and mechanism of action studies of plant-derived compounds play a critical role in drug discovery. The knowledge of the bioactivity of natural compounds can lead to a number of advantages: first of ...