Sfoglia per Autore "Giudice, Valentina"

Items 1-8 di 8

    • 67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach? 

      Montuori, Nunzia; Pesapane, Ada; Giudice, Valentina; Serio, Bianca; Rossi, Francesca Wanda; De Paulis, Amato; Selleri, Carmine (2016)
      The 67 kDa laminin receptor (67LR) is a non-integrin cell surface receptor for laminin (LM) that derives from a 37 kDa precursor (37LRP). 67LR expression is increased in neoplastic cells and correlates with an enhanced ...

    • A Case Series of Blastic Plasmacytoid Dendritic Cell Neoplasia 

      Serio, Bianca; Giudice, Valentina; D'Addona, Matteo; Guariglia, Roberto; Gorrese, Marisa; Bertolini, Angela; D'Alto, Francesca; Cuffa, Bianca; Pellegrino, Daniela; Langella, Maddalena; Selleri, Carmine (2020)
      Blastic plasmacytoid dendritic cell neoplasm (BPDCN), an extremely rare and aggressive tumor, derives from plasmacytoid dendritic cell precursors and is characterized by CD4 and CD56 positivity accompanied by the expression ...

    • Accelerated bone mass senescence after hematopoietic stem cell transplantation 

      Serio, Bianca; Pezzullo, Luca; Fontana, Raffaele; Annunziata, Silvana; Rosamilio, Rosa; Sessa, M.; Giudice, Valentina; Ferrara, Ida Lucia; Rocco, Monia; De Rosa, Gennaro; Ricci, P.; Tauchmanovà, Libuse; Montuori, Nunzia; Selleri, Carmine (2013)
      Osteoporosis and avascular necrosis (AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation (HSCT). We describe the magnitude of bone loss, AVN and impairment in osteogenic ...

    • Immunological derangement in Hypocellular Myelodysplastic Syndromes 

      Serio, Bianca; Risitano, Antonio M.; Giudice, Valentina; Montuori, Nunzia; Selleri, Carmine (2014)
      Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ...

    • In vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cells 

      Giudice, Valentina; Ricci, Pier Carlo; Marino, Luigi; Rocco, Mattia; Villani, Gaetano; Langella, Monica; Manente, Lisa; Seneca, Elisa; Ferrara, Idalucia; Pezzullo, Luca; Serio, Bianca; Selleri, Carmine (2016)
      Farnesyltransferase inhibitors (FTIs) are a class of oral anti-cancer drugs currently tested in phase I-II clinical trials for treatment of hematological malignancies. The in vitro effects of various FTIs (alpha-hydr ...

    • OPSI threat in hematological patients 

      Serio, Bianca; Pezzullo, Luca; Giudice, Valentina; Fontana, Raffaele; Annunziata, Silvana; Ferrara, Ida Lucia; Rosamilio, Rosa; De Luca, C.; Rocco, Monia; Montuori, Nunzia; Selleri, Carmine (2013)
      Overwhelming post-splenectomy infection (OPSI) is a rare medical emergency, mainly caused by encapsulated bacteria, shortly progressing from a mild flu-like syndrome to a fulminant, potentially fatal, sepsis. The risk of ...

    • Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment 

      Rosamilio, Rosa; Giudice, Valentina; Ferrara, Idalucia; Annunziata, Silvana; Pezzullo, Luciano; Villani, Gaetano; Baldi, Carlo Eugenio; Guariglia, Roberto; Rocco, Mattia; Selleri, Carmine (2016)
      T-large granular lymphocyte leukemia (T-LGLL) is a chronic clonal proliferation of effector memory cytotoxic CD3+CD57+CD56- T cells and the current guidelines suggest immunosuppressive therapy as first-line therapy, ...

    • Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer 

      Montuori, Nunzia; Pesapane, Ada; Rossi, Francesca Wanda; Giudice, Valentina; De Paulis, Amato; Selleri, Carmine; Ragno, Pia (2016)
      The urokinase (uPA)-type plasminogen activator receptor (uPAR) is a GPIanchored receptor that focuses urokinase (uPA) proteolytic activity on the cell surface. uPAR also regulates cell adhesion, migration and ...