Browsing by Author "Lamberti, Gaetano"
Now showing items 1-9 of 9
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Analysis and modeling of the behavior of hydrogels-based systems for biomedical and agro-food applications
(Universita degli studi di Salerno, 2017-04-21)Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids. Depending on the type of polymer, number of cross-links, presence of ionic species the ... -
Designing in-vitro systems to simulate the in-vivo permeability of drugs
(2014)In this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several ... -
An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
(2012)In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ... -
In silico and in vitro models in pharmacokinetic studies
(Universita degli studi di Salerno, 2015-04-21)One of the aims of the thesis was to design and realize an in vitro device able to reproduce the gastrointestinal behavior. To reproduce the temperature and pH history an USP apparatus II coupled with a control system ... -
Nanostructured vectors for the transport of active molecules through biological membranes for pharmaceutical and nutraceutical applications
(Universita degli studi di Salerno, 2017-04-27)Purpose of the PhD thesis was to develop dedicated lipid nanostructured vectors with tailored features (in terms of size, surface charge, load capability, stimuli responsive ability and stability) through the design of ... -
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ... -
Process innovation in the production of chelates for agricultural uses
(Universita degli studi di Salerno, 2016-04-13)Analyzing the literature available on the production of iron chelates, it is clear as these extremely diffused products are produced according to processes developed in the second part of last century which involve the ... -
Relevant phenomena and process parameters in granulation for manufacturing of pharmaceutical, nutraceutical and zootechnical products
(Universita degli studi di Salerno, 2019-03-13)Wet granulation is a size enlargement process used in many fields, such as pharmaceutical, nutraceutical, zootecnichal, etc., due its ability to improve technological properties of the final product, compared to the powder ... -
SiRNA delivery for control of cyclin d1 and e2f1 expression in crohn’s disease
(2017)Evidence in inflammatory bowel diseases (IBD) supports a connection between inflammation and cancer due to the alteration of the cell cycle with loss of control at the G1/S checkpoint. In this study, we analyze ...
