• A study protocol for development and validation of a clinical prediction model for frailty (ModulEn): a new European commitment to tackling frailty 

      Apóstolo, Joao; Bobrowicz-Campos, Elzbieta; Moreno-Casbas, Teresa; Teixeira-Santos, Luisa; Sánchez de Madariaga, Ricardo; Casado-Ramírez, Elvira; Couto, Filipa; Coelho, Adriana Neves; Parola, Vitor; Gil, Isabel María; Pascual-Carrasco, Mario; Almeida, Maria de Lurdes; ModulEn consortium (2019)
      There is a growing need to implement and evaluate the technological solutions that allow the early detection of age-related frailty and enable assessment of the predictive values of frailty components. The broad use ...
    • An interregional, transdisciplinary and good practice-based approach for frailty: the mind&gait project 

      Apóstolo, Joao; Couto, Filipa; Bobrowicz-Campos, Elzbieta; Dixe, Maria A.; Ribeiro, Jaime; Braúna, Monica; Camacho, Timoteo; Santos-Rocha, Rita; Parreira, Pedro; Cruz, Armenio; Malça, Cândida; Dantas, Carina; Jegundo, Ana Luisa; Marcelino, Luis; Simões, Mara; Almeida, Maria (2019)
      Social facilities such residential structures and day-centres increasingly seek integrated, structured, adapted, creative, dynamic and economic strategies to prevent frailty. The arising need of an aged and frail ...
    • Assessing the impact of frailty on cognitive function in older adults receiving home care 

      Kleisiaris, Christos; Kaffatou, Eleni Maria; Papathanasiou, Ionna; Androulakis, Emmanouil; Panagiotakis, Simeon; Alvino, Serena; Tziraki, Chariklia (2019)
      It is commonly accepted that frailty and dementia-related cognitive decline are strongly associated. However, degree of this association is often debated, especially in homebound elders with disabilities. Therefore, ...
    • How healthy is community-dwelling elderly population? Results from southern Italy 

      Guerriero, Francesca; Orlando, Valentina; Tari, Daniele Ugo; Di Giorgio, Annalisa; Cittadini, Antonio; Trifirò, Gianluca; Menditto, Erica (2015)
      PURPOSE To explore the frequency of polypharmacy, functional and cognitive capacity among the elderly in Southern Italy. METHODS Populationbased retrospective cross-sectional study. Information were retrieved from ...
    • Immunologic Changes in Frail Older Adults 

      Wang, George C.; Casolaro, Vincenzo (2014)
      Several studies have shown a heightened inflammatory state in frail older adults, marked by high serum levels of interleukin-6 and C-reactive protein and an increased number of circulating leukocytes. Activation of monocytes ...
    • Integrated care models for managing and preventing frailty: A systematic review for the European Joint Action on Frailty Prevention (ADVANTAGE JA) 

      Hendry, Anne; Vanhecke, Eliane; Carriaz, Ana Maria; López-Samaniego, Luz; Espinosa, Juan Manuel; Sezgin, Duygu; O’Donovan, Mark; Hammar, Teija; Ferry, Peter; Vella, Antoine; Bacaicoa, Olatz Albaina; Braga, Mario; Ciutan, Marius; Velivasi, Alexandra; Lamprini, Koula Maria; Van der Heyden, Johan; Liew, Aaron; O'Caoimh, Rónán
      Frailty requires concerted integrated approaches to prevent functional decline. Although there is evidence that integrating care is effective for older people, there is insufficient data on outcomes from studies ...
    • Models for preclinical studies in aging-related disorders: one is not for all 

      Santulli, Gaetano; Borras, Consuelo; Bousquet, Jean; Calzà, Laura; Cano, Antonio; Illario, Maddalena; Franceschi, Claudio; Liotta, Giuseppe; Maggio, Marcello; Molloy, William D.; Montuori, Nunzia; O’Caoimh, Rónán; Orfila, Francesco; Rauter, Amelia P.; Santoro, Aurelia; Iaccarino, Guido (2015)
      Preclinical studies are essentially based on animal models of a particular disease. The primary purpose of preclinical efficacy studies is to support generalization of treatment–effect relationships to human subjects. ...
    • The european innovation partnership on active and healthy ageing synergies: protocol for a prospective observational study to measure the impact of a community-based program on prevention and mitigation of frailty (ICP –PMF) in community-dwelling older adults 

      Liotta, Giuseppe; Orfila, Francesc; Vollenbroek-Hutten, Miriam; Roller-Winsbergerm, Regina; Musian, Daniele; Alvino, Sam; O'Caoimh, Ronan; Cano, Antonio; Molloy, William; Iaccarino, Guido; Marazzi, Maria Cristina; Inzerilli, Maria Chiara; Madaro, Olga; Paúl, Constança; Csonka, Peter; Menditto, Enrica; Maggio, Maria; Scarcella, Paola; Gilardi, Fabrizio; Lucaroni, Francesca; Abete, Pasquale; Girardi, Viviane; Barra, Rita; Palombi, Leonardo (2016)
      Aim of this paper is to describe the protocol of the study “Impact of a Community-based Program on Prevention and Mitigation of Frailty in communitydwelling older adults” developed in the framework of the European ...