http://elea.unisa.it/xmlui/handle/10556/2092 2026-04-20T11:30:34Z 2026-04-20T11:30:34Z Vollenbroek-Hutten, Miriam Pais, S Ponce, S Dekker-van Weering, Marit Jansen-Kosterink, Stephanie Schena, F Tabarini, N Carotenuto, F Iadicicco, V Illario, M. http://elea.unisa.it/xmlui/handle/10556/3783 2025-04-30T14:31:34Z 2015-01-01T00:00:00Z

Rest Rust! Physical active for active and healthy ageing Vollenbroek-Hutten, Miriam; Pais, S; Ponce, S; Dekker-van Weering, Marit; Jansen-Kosterink, Stephanie; Schena, F; Tabarini, N; Carotenuto, F; Iadicicco, V; Illario, M. The aim of this paper is to give an insight on how physical activity can be defined, parameterized and measured in older adults and on different options to deal with citizen physical activity promotion at European level. Three relevant aspects are highlighted: 1. When talking about physical activity, two different aspects are often unfairly mixed up: “physical activity” and “physical capacity”. • Physical activity, is referred to as the level of physical activity someone is actually performing in daily life. • Physical capacity is referred to as the maximum physical activity a person can perform. 2. Both physical activity and physical capacity can be expressed in different dimensions such as time, frequency, or type of activity with the consequence that there are many tools and techniques available. In order to support people to choose an appropriate instrument in their everyday practice a list of 9 criteria that are considered important is defined. 3. Older adults score differently across the various physical dimensions, so strategies to promote physical activity should consider individual differences, in order to adapt for these variations.

2015-01-01T00:00:00Z Marzetti, E. Calvani, R. Cesari, M. Tosato, M. Cherubini, A. Di Bari, M. Pahor, M. Savera, G. Collamati, A. D'Angelo, E. Bernabei, R. Landi, F. http://elea.unisa.it/xmlui/handle/10556/3782 2025-04-30T14:34:06Z 2015-01-01T00:00:00Z

Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation Marzetti, E.; Calvani, R.; Cesari, M.; Tosato, M.; Cherubini, A.; Di Bari, M.; Pahor, M.; Savera, G.; Collamati, A.; D'Angelo, E.; Bernabei, R.; Landi, F. Over the years, different operational definitions have been elaborated to identify frail older persons, but none of them has received unanimous consensus. This, in turn, has hampered the clinical implementation of frailty as well as the design of targeted interventions. To overcome the current limitations in the field, a novel operationalization of physical frailty (PF) is proposed which grounds its roots in the recognition of sarcopenia as its central biological substrate. This conceptualization is based on the fact that the clinical picture of PF overlaps substantially with that of sarcopenia. The two conditions may therefore be merged into a new clinical entity, the PF & sarcopenia (PF&S) syndrome, in which muscle loss represents both the biological substrate for the development of PF and a major pathway whereby the negative health outcomes of PF occur. All of the components defining the PF&S syndrome are measurable in an objective manner, which will facilitate its incorporation into standard practice. The recognition of a precise biological substratum for PF&S (i.e., skeletal muscle decline) also opens new venues for the development of preventive and therapeutic interventions.

2015-01-01T00:00:00Z Di Furia, L. Rusciano, M. R. Leonardini, L. Rossi, P. Giammarchi, C. Tilocca, S. Russo, F. L. Montuori, P. Triassi, M. Nardone, A. Giaimo, M. D. Migazzi, M. Piffer, S. Iaria, A. Trapasso, A. Firenze, A. Cristaudo, R. Revello, M. Castiglion, A. Zagonel, V. Iaccarino, G. Addis, A. Natale, L. Di Somma, C. Colao, A. Perra, A. Giova, K. Illario, M. http://elea.unisa.it/xmlui/handle/10556/3781 2025-04-30T14:34:21Z 2015-01-01T00:00:00Z

A nutritional approach to the prevention of cancer: from assessment to personalized intervention Di Furia, L.; Rusciano, M. R.; Leonardini, L.; Rossi, P.; Giammarchi, C.; Tilocca, S.; Russo, F. L.; Montuori, P.; Triassi, M.; Nardone, A.; Giaimo, M. D.; Migazzi, M.; Piffer, S.; Iaria, A.; Trapasso, A.; Firenze, A.; Cristaudo, R.; Revello, M.; Castiglion, A.; Zagonel, V.; Iaccarino, G.; Addis, A.; Natale, L.; Di Somma, C.; Colao, A.; Perra, A.; Giova, K.; Illario, M. Among lifestyle factors, nutrition is one of the most important determinants of health, and represents a pivotal element of cancer risk. Nonetheless, epidemiological evidences of the relationship between several cancers and specific foods and nutrients is still inadequate, and solid conclusions are missing. Indeed, caloric restriction without malnutrition is associated to cancer prevention. Food may be also the primary route of exposure to contaminants such as metals, persistent organic pollutants, and pesticides. Exposuredisease associations and the interplay with genetic susceptibility requires further studies on genetic variation, environment, lifestyle, and chronic disease in order to eliminate and reduce associated health risks, thus contributing to improve health outcomes for the population. A primary nutritional approach for Active and Healthy Ageing (AHA) has been developed by the Nutrition group of the European Innovation Partnership (EIP) on AHA. The working group on lifestyles of the Italian Ministry of Health has developed a comprehensive approach to adequate nutrition using a consensus methodology to collect and integrate the available evidences from the literature and from the Italian experiences at the regional level, to raise the interest of other experts and relevant stakeholders to outline and scale-up joint strategies for a primary nutritional approach to cancer prevention.

2015-01-01T00:00:00Z Corbi, G. Conti, V. Filippelli, A. Di Costanzo, A. Ferrara, N. http://elea.unisa.it/xmlui/handle/10556/3780 2025-04-30T14:34:30Z 2015-01-01T00:00:00Z

The role of physical activity on the prevention of cognitive impairment Corbi, G.; Conti, V.; Filippelli, A.; Di Costanzo, A.; Ferrara, N. Physical exercise is associated with reduced risk of heart disease, type II diabetes mellitus, and overall mortality. However, growing evidence shows that physical activity can also improve cognitive function and may lower the risk of developing dementia, but Randomized Clinical Trials gave mixed results. Aim of this article was to review the knowledge available in literature on the effects of physical activity on cognition and the suggested possible mechanisms involved in these effects. Our group have planned a trial aiming to evaluate the effectiveness of physical activity in preventing or delaying the cognitive decline in individuals at risk of developing dementia. Beside the effects of exercise on cognition are not fully defined, also the mechanisms underlying the benefits of physical activity on cognitive sphere are not completely known. Recently the SIRT1 loss is both closely associated with accumulation of beta amyloid and tau protein in AD patients. Although there is no specific exercise that can be recommended, the available evidence suggests that practicing more types of physical activity is particularly advantageous. It is important to explore further mechanisms involved in the pathogenesis of the AD in order to be able to identify new and effective target treatment, including physical activity.

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