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Sfoglia Scienze del farmaco per Data di Immissione 
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Items 21-34 di 34

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      Targeted and untargeted proteomic approaches to disclose small molecules interactome 

      Ferraro, Giusy (Universita degli studi di Salerno, 2023-04-24)
      The identification of natural products and synthetic compounds target proteins is pivotal to understand their mechanism of action for the development of molecular probes and/or potential drugs. Functional proteomics is a ...
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      Development of novel anticancer compounds directed towards promising therapeutic targets 

      Pierri, Martina (Universita degli studi di Salerno, 2023-04-19)
      Lysine acetylation of histone tails is an epigenetic hallmark that plays a crucial role in the regulation of chromatin structure. Alteration in acetylation levels and/or aberrant activity in proteins involved in this crucial ...
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      Molecular mechanisms of TFF1-Helicobacter cross-talk 

      Mentucci, Fatima Maria (Universita degli studi di Salerno, 2023-04-18)
      Helicobacter pylori is one of the most important pathogenic bacteria associated with various gastric diseases, including cancer. This pathogen induces an acute mucosal inflammatory response and, if not eradicated, it could ...
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      Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity 

      Parisi, Valentina (Universita degli studi di Salerno, 2023-04-12)
      This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary part ...
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      Analytical procedures for the safety assessment of dietary supplements and botanicals 

      Rizzo, Serena (Universita degli studi di Salerno, 2023-04-06)
      The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ...
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      Design, synthesis and pharmacological evaluation of new enzyme inhibitors 

      Smaldone, Gerardina (Universita degli studi di Salerno, 2023-04-13)
      My PhD research plan relates to the exploration of the structural requirements for the modulation of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part of my doctoral project ...
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      Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein 

      Firoznezhad, Mohammad (Universita degli studi di Salerno, 2022-04-26)
      Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile che include il peptide di ...
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      Design and synthesis of small molecules as ion channel modulators 

      Vestuto, Vincenzo (Universita degli studi di Salerno, 2022-05-02)
      My PhD research plan relates the exploration of the structural requirements for ionic channels modulation such as TRPM8 and Kv7 receptors. About the first field, we prepared a series of tryptophan-based derivatives of our ...
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      High-throughput virtual screening by molecular dynamics assisted molecular docking. 

      Nardiello, Anna Maria (Universita degli studi di Salerno, 2022-04-29)
      Molecular docking is a widely used Structure-Based method for drug discovery. Over the years, molecular docking methodologies have evolved to address several limitations, such as high errors in predicting pose and binding ...
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      Development of Innovative Agents for the Treatment of Metabolic Diseases 

      D’Aulisio Garigliota, Maria Luisa (Universita degli studi di Salerno, 2022-05-10)
      Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the leading cause of death in the world. To date three main therapeutic strategies have been evaluated to reduce circulating LDL-C ...
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      Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases) 

      Iannelli, Giulia (Universita degli studi di Salerno, 2022-05-03)
      La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La metilazione dell'arginina ...
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      Role of H3K56 acetylation in Candida albicans virulence 

      Conte, Marisa (Universita degli studi di Salerno, 2022-12-20)
      Candida spp., especially Candida albicans, represent the third most frequent cause of infection in Intensive Care Units worldwide, with a mortality rate approaching 40%. The increasing antifungal resistance drastically ...
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      Effects of natural iron chelators on dendritic cells: anti-inflammatory activity, phenotypic characterization, and metabolomic analysis 

      Verna, Giulio (Universita degli studi di Salerno, 2022-12-16)
      Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate the adaptive ...
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      Design and synthesis of molecules with anti-inflammatory and/or anti-cancer activit 

      Colarusso, Ester (Universita degli studi di Salerno, 2022)
      Nell'ultimo decennio, il legame tra infiammazione e cancro è risultato sempre più evidente; di conseguenza, l'identificazione di nuove molecole in grado di interferire con i targets biologici chiave coinvolti in queste ...
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