The treatment of metastatic melanoma was revolutionized by the approval of inhibitors of immune-checkpoints, including antibodies targeting the programmed cell death protein 1 (PD- 1), such as nivolumab and pembrolizumab. ...

The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ...

Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...

Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...