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NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(2017-03-30)
Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite
concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle,
environment, stimuli and genetic ...
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(2022-04-27)
There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to
characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ...
Design and synthesis of small molecules as ion channel modulators
(2022-05-02)
My PhD research plan relates the exploration of the structural requirements for ionic channels
modulation such as TRPM8 and Kv7 receptors.
About the first field, we prepared a series of tryptophan-based derivatives of our ...
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(2017-03-31)
Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert
beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties
of bioactive extracts ...
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(2022-04-26)
Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono
la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile
che include il peptide di ...
Development of Innovative Agents for the Treatment of Metabolic Diseases
(2022-05-10)
Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the
leading cause of death in the world. To date three main therapeutic strategies have been evaluated to
reduce circulating LDL-C ...
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(2023-04-13)
My PhD research plan relates to the exploration of the structural requirements for the modulation
of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part
of my doctoral project ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...
Effects of natural iron chelators on dendritic cells: anti-inflammatory activity, phenotypic characterization, and metabolomic analysis
(2022-12-16)
Dendritic cells (DCs) are key regulators of the immune system that patrol all the compartments of the
body. When exposed to danger signals, DCs mature, migrate to the draining lymph nodes, and activate
the adaptive ...