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An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
(2012)
In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ...
Pharmacokinetics of remifentanil: a three-compartmental modeling approach
(2013)
Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics ...
Designing in-vitro systems to simulate the in-vivo permeability of drugs
(2014)
In this work an engineering approach,
consisting in an experimental procedure and a model to
derive the data, was presented and applied to improve the
testing methods of pharmaceuticals. The permeability of
several ...
SiRNA delivery for control of cyclin d1 and e2f1 expression in crohn’s disease
(2017)
Evidence in inflammatory bowel diseases (IBD)
supports a connection between inflammation and cancer
due to the alteration of the cell cycle with loss of control
at the G1/S checkpoint. In this study, we analyze ...