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Design and synthesis of modulators of apoptotic activity
(2016-03-23)
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...
Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(2016-04-21)
A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ...
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(2016-05-04)
The design of new metal complexes as anticancer agents has received considerable interest in
recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.:
texaphyrrins lanthanide) and ...
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(2016-04-20)
The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ...