Cerca
Items 1-4 di 4
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(2013-04-03)
The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ...
Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases)
(2017-03-27)
JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ...
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(2016-04-20)
The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ...
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(2018-04-20)
Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ...