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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products 

De Simone, Rosa (2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
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Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs 

Cafaro, Emiddio (2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical. L'interesse destato da questi metaboliti secondari è ...
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Chemical proteomics on ligand protein 

Margarucci, Luigi (2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
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Enzymatic synthesis of macrolactones 

Fortunati, Tancredi (2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a macrolactone structure have been isolated from many natural sources such as plants, insects, marine organism and bacteria. ...
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AutoreCafaro, Emiddio (1)De Simone, Rosa (1)Fortunati, Tancredi (1)Margarucci, Luigi (1)Soggetto
CHIM/06 CHIMICA ORGANICA (4)
Azumammidi (1)Click chemistry (1)HDACs (1)Lipase (1)Macrolactones (1)Mass spectrometry (1)mPGES-1 (1)Natural product (1)Proteomics (1)... View MoreDate Issued
2011 (4)
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