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Design, synthesis, biological evaluation and binding studies of new small-molecule modulators of KDMs (lysine-specific demethylases) 

Balzano, Amodio Luca (2017-03-27)
JHDMs (JmjC-domain-containing histone demethylases) are the largest class of demethylase enzymes, contain a Jumonji C (JmjC) domain and catalyze lysine demethylation of histones through an oxidative reaction that requires ...
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NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases 

Palisi, Angelica (2017-03-30)
Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ...
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In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being 

Moccia, Stefania (2017-03-31)
Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive extracts ...
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Design, synthesis, biological studies of new mitochondrial modulators improving neurological deficits in experimental models of Huntington's disease 

Di Cristo, Francesca (2017-03-22)
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Design and synthesis of peptides involved in the inhibition of influenza virus infection 

Scala, Maria Carmina (2017-03-28)
The main purpose of the present research project was the identification of peptide capable of exercising potent anti-influenza activity. We identified bovine lactoferrin (bLf) as drug target, a multifunctional glycoprotein ...
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Design and synthesis of new integrase inhibitors 

Spensiero, Antonia (2017-03-28)
The viral enzyme integrase (IN) is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents an important target for the development of new antiretroviral drugs. In this PhD project, we ...
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Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents 

Foglia, Antonio (2017-03-22)
One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
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AutoreBalzano, Amodio Luca (1)Di Cristo, Francesca (1)Foglia, Antonio (1)Moccia, Stefania (1)Palisi, Angelica (1)Scala, Maria Carmina (1)Spensiero, Antonia (1)Soggetto
CHIM/08 CHIMICA FARMACEUTICA (7)
Antioxidant (1)Biginelli reactions (1)Biomarkers (1)Bovine lactoferrin (1)Demethylases (1)Epigenetics (1)Extract (1)HIV-1 (1)HspSO (1)... View MoreDate Issued
2017 (7)
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EleA themes by Ugsiba