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Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
Computational chemistry techniques for the design and the synthesis of molecules with anti-inflammatory and anti-tumor activity
(2019-06-18)
In the last few years, computational chemistry has played an important role in disclosing novel compounds with relevant biological activity. Inflammation and cancer processes have been recently linked, and the identification ...