Chimica: Recent submissions
Items 21-40 di 93
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The Role of ABCC6 Transporter in the Purinergic System: from Oncology to Regenerative Medicine
(Universita degli studi di Salerno, 2022-06-20)ABCC6 is a member of ATP-binding cassette family of transporters, a class of membrane transporters sharing a common structural organization. Mutations in ABCC6 are associated with Pseudoxantoma elasticum (PXE) and with a ... -
Capsicum annuum L.cv senise and solanum aethiopicum L.cv Rotonda: phytochemical profile and cell-based assays
(Universita degli studi di Salerno, 2021-05-10)Natural products rich in health-promoting compounds could represent new potential therapy strategy in many diseases. In the present study we focus our attention on Capsicum annuum L. cv Senise and Solanum aethiopicum L. ... -
Combined adsorption and solar driven photocatalysis processes for the removal of persistent contaminants from water by highly porous nanocomposite aerogels
(Universita degli studi di Salerno, 2021-07-26)Water is a very important resource for human and ecosystem. However, in recent years the presence of pollutants, such as pharmaceuticals, cosmetics, personal cares, dyes, and pesticides deriving from industrial, agricultural, ... -
Solid state dynamic behaviour of organic molecules
(Universita degli studi di Salerno, 2020-02-13)The main interactions characterizing the crystals of organic molecules are weak interactions such as hydrogen bonds, van der Waals forces, hydrophobic interactions, etc.1 Considering the weak nature of the forces involved, ... -
Dynamical control of engineered stimuli-responsive materials: synthesis and optimization of active micro-vesicles
(Universita degli studi di Salerno, 2020-02-14)The aim of this PhD project is the combination of a pH clock reaction (the enzymatic urea-urease reaction) with pH-responsive materials to generate a chemo-mechanical coupling. A clock reaction is characterized by a latent ... -
Study on calixarene threading: towards molecular machines
(Universita degli studi di Salerno, 2021-05-11)Negli ultimi tre decenni, l'uso dei calixareni come host macrociclici nella chimica supramolecolare ha acquisito una rilevanza crescente, soprattutto per la costruzione di macchine molecolari. Pertanto, è importante capire ... -
Bioinspired supramolecular catalysis in nanoconfined space
(Universita degli studi di Salerno, 2021-04-17)The nanoconfinement in Nature is the key for the selectivity of enzymatic reactions: when the substrates are confined in the enzyme pocket, overconcentration and proximity effects promote the reaction in very efficient and ... -
Elucidation of crystal structures and structural changes using X-ray powder diffraction
(Universita degli studi di Salerno, 2021-03-12)In the process of understanding the properties and behaviour of a compound, and designing improved materials, probing the atomic-level structure is a decisive step. Single crystal X-ray diffraction, a widespread, non-destructive ... -
Molecular cartography of the metabolome of typical food products of the Basilicata region by using high resolution mass spectrometry
(Universita degli studi di Salerno, 2021-05-19)I marchi di Designazione di Origine Protetta (DOP) e di Indicazione Geografica Protetta (IGP), insieme a quello relative alle Specialità Tradizionali Garantite (STG), sono strumenti creati dall’Unione Europea (UE) che ... -
Stereoselectivity in asymmetric processes and molecular assemblies
(Universita degli studi di Salerno, 2020-02-19)The aim of this thesis was to explore different areas of organic chemistry in which the stereocontrol in the design of chemical processes and/or molecular assemblies is necessary. Therefore, the stereoselectivity in ... -
Comparative studies on the physiological adaption of mitochondria and endoplasmic reticulum to envirnmental xenobiotics from invertebrate to mammals
(Universita degli studi di Salerno, 2021-04-20)Mitochondria are critical for numerous cellular and biochemical processes. The reciprocal interaction between mitochondria and the endoplasmic reticulum impacts several cellular functions. In cellular and animal models, ... -
Development of eco-sustainable methodologies for innovative materials inspired by cellulose fibers
(Universita degli studi di Salerno, 2021-04-28)This PhD is an “Industrial-PhD”, carried out in collaboration between University of Basilicata and LUCART S.p.A (Porcari, Lucca, Italy), in that case with the plant located at Avigliano (Potenza, Italy). The scholarship ... -
Synthesis of new water reducer superplasticizers for building materials
(Universita degli studi di Salerno, 2021-07-18)This industrial PhD project is focused on the development of new additives called Superplasticizers (SPs) that are particularly interesting for the engineering of construction field. These attracting molecules are organic ... -
New applications of Ester/Amide surrogates in organic synthesis
(Universita degli studi di Salerno, 2021-04-22)Masked esters/amides are scaffolds endowed with a great potential in the field of organic synthesis. This PhD project has been conceived, in the context of non-covalent organocatalysis, with the aim to exploit unsaturated ... -
Supported gold nanoparticles as promising catalysts in sustainable organic synthesis
(Universita degli studi di Salerno, 2021-03-23)Gold nanoparticles (AuNPs) emerged as very promising catalysts in a lot of organic reactions and industrial applications. These catalysts are in fact capable of catalysing chemical processes under mild conditions and according ... -
Olive oil and oleate affect hepatic proteome and mitochondrial dynamics: in vivo and in vitro approaches
(Universita degli studi di Salerno, 2021-05-27)The Mediterranean diet (MD) has been pointed out as a nutritional approach to prevent metabolic disturbances leading to obesity, diabetes and liver steatosis. These properties have been largely attributed to oleic acid and ... -
New perspectives in phase transfer catalysis
(Universita degli studi di Salerno, 2020-02-11)The increasing demand for the stereoselective synthesis of bioactive compounds in both industrial and academic research has led to the rapid development of a variety of diastereo- and enantio-selective processes using phase ... -
Heterocyclic architecture for the synthesis of anti-HIV protease and anti-cancer compounds
(Universita degli studi di Salerno, 2020-02-14)Introduction of heterocycle moieties in a bioactive molecule can have important effects on physicochemical and pharmacological properties, because of their chemical stability, their structural rigidity and due to the ... -
Chiral Bioactive Cyclopeptoids: Concepts and Purposes
(Universita degli studi di Salerno, 2020-02-09)Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ... -
Development and optimization of analytical methods for the analysis of drugs in wastewater samples and chronic aquatic toxicity assessment of the Crustacea Copepoda Tigriopus fulvus
(Universita degli studi di Salerno, 2020-02-13)Pharmaceutical compounds constitute one of the most important emerging classes of environmental pollutants. Recent studies have discovered their occurrence in environmental samples investigated worldwide, including different ...