BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating ...

TFF1 is a protein expressed in the gastrointestinal tract, belonging to the trefoil folding factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a cloverleaf disulfide ...

My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...

This project was aimed at enhancing the synthesis of tri-cyclic bioactive abietane diterpenes (e.g. aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol), synthesized in the roots of Salvia sclarea and other Salvia ...

Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ...

In recent years, environmental pollution, particularly air pollution, is a subject of great scientific and public interests. The reason is due to the strong impact on human health. Air pollution is due to the placing in ...

Bcl-2-associated athanogene 3 (BAG3) belongs to the family of co-chaperone proteins that interact with the heat shock protein 70 (Hsp70) and is involved in a number of cellular processes including proliferation and apoptosis. ...

Lifestyle and food choices have an important role in the onset and in the prevention of some diseases. The assumption of some food-related molecules can have different effects on human health; for example, the antioxidants ...

The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored cell surface receptor. uPAR expression is strongly up-regulated and represents a negative prognostic factor in various tumors, including ...

Glioma is a fatal disease characterized by uncontrolled cellular proliferation and it is the most common primary brain malignancy in adults. Despite years of research, malignant glioma remains one of the most aggressive ...