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A multi-disciplinary approach based on mass spectrometry to disclose the potential of phytoextracts as natural cosmetics
(Universita degli studi di Salerno, 2023-04-09)Plant cells represent a valid source of cosmetic ingredients since their extracts can be considered bio-sustainable, contaminant-free and standardized secondary metabolites mixtures (Barbulova et al., 2014). This PhD project ... -
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(Universita degli studi di Salerno, 2022-10-20)Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D printing process ... -
Analisi funzionale del gene UVR8 e suo ruolo nella risposta delle piante a stress ambientali
(Universita degli studi di Salerno, 2015-07-16)Plants are sessile organisms and, therefore, are continuously subjected to environmental sub-optimal or stressful conditions. In an arid environment plants are challenging multiple stresses, such, as water shortage, excessive ... -
Analysis and evaluation of potential nutracentical milk and dairy products derived from the Centrale del latte di Salerno
(Universita degli studi di Salerno, 2015-03-16)The main objective of my PhD has been focused to the analysis and characterization of milk and dairy products derived from “Centrale del Latte di Salerno” in order to assess their potential use as dietary supplements and ... -
Analytical procedures for the safety assessment of dietary supplements and botanicals
(Universita degli studi di Salerno, 2023-04-06)The consumption of dietary supplements and botanicals is not always safe and free of potential health risks. In recent years, cases of contamination with hepatotoxic pyrrolizidine alkaloids, a group of plant secondary ... -
Annexin A1 in pancreatic cancer progression
(Universita degli studi di Salerno, 2022-02-02)Pancreatic cancer (PC) is one of the most aggressive cancers in the world and it correlates to poor prognosis and high mortality due to late diagnosis, even if early diagnosed. Resectable PC patients have unfavorable outcome ... -
Antioxidative and antisenescent effects of cardiac rehabilitation in heart failure patients
(Universita degli studi di Salerno, 2016-04-26)Exercise-based cardiac rehabilitation (CR) is effectively used as an adjuvant therapy in a number of cardiovascular diseases (CVDs), including chronic heart failure (CHF), and it is recommended by the American and European ... -
Application of Artificial Neural Networks to the design and optimization of superhydrophobic coatings
(2021-05-19)Recently, considerable attention has been devoted to developing superhydrophobic surfaces due to their advantageous antimicrobial and self-cleaning properties. While significant effort has been devoted to their fabrication, ... -
BAG3 extracellulare: target cellulari e molecolari
(Universita degli studi di Salerno, 2016-07-12)Bcl-2-associated athanogene 3 (BAG3) belongs to the family of co-chaperone proteins that interact with the heat shock protein 70 (Hsp70) and is involved in a number of cellular processes including proliferation and apoptosis. ... -
BAG3 role in cardiomyocytes physiopathology
(Universita degli studi di Salerno, 2013-01-31)The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful ... -
Bioactives from agricultural food by-products: application in food and health
(Universita degli studi di Salerno, 2017-04-04)Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ... -
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(Universita degli studi di Salerno, 2016-04-20)The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ... -
Biophysical investigation of biomolecules in bio-membrane models
(Universita degli studi di Salerno, 2012-05-30)Many drugs are available for the treatment of systemic or superficial mycoses, but only a limited number of them are effective antifungal drugs, devoid of toxic and undesirable side effects. Therefore there remains an ... -
Bioprospecting of plants from Campania region to promote the sustainable use of biodiversity
(Universita degli studi di Salerno, 2023-04-12)This research aimed to chemical-biological study of plant and fungal species from inland areas of Campania Region, typically used in preparations for medicinal purposes or food traditional recipes. In the preliminary part ... -
Characterization and biological properties of Citrus industrial derivatives and waste products for the formulation of nutraceuticals
(Universita degli studi di Salerno, 2015-03-16)Polyphenols are natural chemical compounds, common in higher plants as and particularly known and appreciated for their health properties. We focused attention on Citrus bergamia, Citrus sinensis, Mela annurca and Vitis ... -
Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)The research project "Chemical and biological study of natural substances active on the Central Nervous System" has been focused on the possible effects of essential oils, their main constituents (in particular monoterpenes), ... -
Chemical proteomics on ligand protein
(Universita degli studi di Salerno, 2011-03-18)The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ... -
Chimica e attività biologica di specie del genere Hypericum
(Universita degli studi di Salerno, 2013-01-14)Lo scopo di questo progetto di ricerca è stato lo studio chimico e biologico di quattro specie del genere Hypericum: H. peforatum L., H. connatum Lam, H. hircinum L., H. perfoliatum L. Nella prima fase, è stato identificato ... -
Chronotherapeutic Drug Delivery in Early Morning Pathologies: Design and Production of new NSAIDs/SAIDs polysaccharide-based systems
(Universita degli studi di Salerno, 2017-03-28)The major technological challenge encountered when formulating new dosage forms is to find a way to adapt drug release kinetics to specific clinical requirements, with the aim to enhance the therapeutic action of both new ... -
Circulating sortilin level as a potential biomarker for endothelial dysfunction and hypertension
(Universita degli studi di Salerno, 2022-03-16)Sortilin has been positively correlated with vascular disorders in humans. Previous studies showed that sortilin promotes activation of acid sphingomyelinase (ASMase) and subsequently induces an increase of nicotinamide ...
