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Translational pharmacogenomics: a study of warfarin dosing
(Universita degli studi di Salerno, 2016-04-21)
Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index, large inter-individual ...
Studio delle relazioni tra alimentazione e stati fisiopatologici mediante un approccio di biologia dei sistemi
(Universita degli studi di Salerno, 2016-09-30)
Lifestyle and food choices have an important role in the onset and in the prevention of
some diseases. The assumption of some food-related molecules can have different
effects on human health; for example, the antioxidants ...
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(Universita degli studi di Salerno, 2016-05-10)
My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...
Design and synthesis of modulators of apoptotic activity
(Universita degli studi di Salerno, 2016-03-23)
p53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] ...
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)
Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation
which represents the prototype of the long pentraxins. In the last years, numerous
studies have correlated the elevated plasma levels ...
Essential Infantile Esotropia with Inferior Oblique hyperfunction and Lateral Recti pseudoparalysis: long term follow-up of 6 muscles approach
(Universita degli studi di Salerno, 2016-04-21)
AIM: Analysis of long-term follow-up (3 months, 2 years, 5 years and 10 years) in Infantile Esotropia patients (IE), after a 6 muscles approach.
METHODS: A 6 muscles approach in IE has been evaluated in patients with ...
Antioxidative and antisenescent effects of cardiac rehabilitation in heart failure patients
(Universita degli studi di Salerno, 2016-04-26)
Exercise-based cardiac rehabilitation (CR) is effectively used as an adjuvant therapy in a number of cardiovascular diseases (CVDs), including chronic heart failure (CHF), and it is recommended by the American and European ...
Identification of new genetic alterations and potential biomarkers in papillary thyroid carcinoma
(Universita degli studi di Salerno, 2016-05-24)
Papillary thyroid carcinoma (PTC) is the most frequent thyroid malignant
neoplasia. Oncogene activation occurs in more than 70% of the cases. BRAF
mutations occur in about 40% of PTCs, whereas RET rearrangements ...
Studio del ruolo della proteina anti-apoptotica BAG3 nel melanoma umano
(Universita degli studi di Salerno, 2016-07-07)
BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating ...
Regolazione post-trascrizionale dell’espressione del recettore dell’urochinasi
(Universita degli studi di Salerno, 2016-12-14)
The urokinase type plasminogen activator (uPAR) is a three domain GPI-anchored
cell surface receptor. uPAR expression is strongly up-regulated and represents a
negative prognostic factor in various tumors, including ...