Area Scienze mediche: Recent submissions
Items 101-120 di 162
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Design, synthesis and biological evaluation of new small-molecule modulators of Protein Methyltransferases (PMTs)
(Universita degli studi di Salerno, 2016-04-21)A large amount of evidences indicate that dysregulation of protein methylation is linked to the genesis and progression of several human diseases, including cancer. Therefore over the past years small-molecule modulators ... -
Essential Infantile Esotropia with Inferior Oblique hyperfunction and Lateral Recti pseudoparalysis: long term follow-up of 6 muscles approach
(Universita degli studi di Salerno, 2016-04-21)AIM: Analysis of long-term follow-up (3 months, 2 years, 5 years and 10 years) in Infantile Esotropia patients (IE), after a 6 muscles approach. METHODS: A 6 muscles approach in IE has been evaluated in patients with ... -
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)The design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and ... -
Progettazione di un biosensore ottico per la determinazione atmosferica del benzene
(Universita degli studi di Salerno, 2016-04-15)In recent years, environmental pollution, particularly air pollution, is a subject of great scientific and public interests. The reason is due to the strong impact on human health. Air pollution is due to the placing in ... -
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ... -
La Pentraxina 3: un potenziale marcatore di danno endoteliale nell’ipertensione arteriosa
(Universita degli studi di Salerno, 2016-04-26)Background - The pentraxin 3 (PTX3) is a protein of the acute phase of inflammation which represents the prototype of the long pentraxins. In the last years, numerous studies have correlated the elevated plasma levels ... -
Regolazione epigenetica dell’espressione del fattore peptidico gastrointestinale TFF1
(Universita degli studi di Salerno, 2016-04-19)TFF1 is a protein expressed in the gastrointestinal tract, belonging to the trefoil folding factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a cloverleaf disulfide ... -
Biomolecular and biophysical approaches to interrogate epigenetic targets: a platform for drug discovery
(Universita degli studi di Salerno, 2016-04-20)The term epigenetics refers to heritable changes in gene expression that do not involve changes in the DNA sequence. A large number of enzymes, which act mainly on histone tails and DNA, carries out epigenetic modifications, ... -
Transcriptional regulation of biosynthetic genes of the plant MEP-derived pathway to boost the metabolic flux towards bioactive diterpenes
(Universita degli studi di Salerno, 2016-02-02)This project was aimed at enhancing the synthesis of tri-cyclic bioactive abietane diterpenes (e.g. aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol), synthesized in the roots of Salvia sclarea and other Salvia ... -
Neuroimmune regulation of JCV by immune mediators in glial cells
(Universita degli studi di Salerno, 2015-04-23)The human polyomavirus JC (JCV) is a small DNA virus responsible for the initiation of progressive multifocal leukoencephalopathy (PML), an often lethal disease of the brain characterized by lytic infection of oligodendrocytes ... -
Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina
(Universita degli studi di Salerno, 2015-04-22)Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it may be a consequence of a reduced availability of this hormone, of an impediment to its normal action, or of a combination ... -
Analisi funzionale del gene UVR8 e suo ruolo nella risposta delle piante a stress ambientali
(Universita degli studi di Salerno, 2015-07-16)Plants are sessile organisms and, therefore, are continuously subjected to environmental sub-optimal or stressful conditions. In an arid environment plants are challenging multiple stresses, such, as water shortage, excessive ... -
Development of analytical methodology for determination of emerging contaminants in enviroment and food
(Universita degli studi di Salerno, 2015-04-24)In recent years, fate, occurrence and potential adverse effect of emerging contaminants (ECs) in the environment have received an increased attention by scientific community. The ECs are a broad category of chemicals, ... -
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(Universita degli studi di Salerno, 2015-04-24)Heterocyles are an essencial class of molecules, assuming a role in many aspect of our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and bioactive compounds including agrochemical products ... -
Hairy root culture as source of novel plant-derived active compounds with applications in cosmetics
(Universita degli studi di Salerno, 2015-04-22)Hyperpigmentation is the process by which an excess of melanin is produced by the skin. Typically, hyperpigmentation occurs as a result of stress, damage or prolonged inflammation of the skin. The most common cause is sun ... -
Compression and indexing of genomic data with confidentiality protection
(Universita degli studi di Salerno, 2015-04-30)The problem of data compression having specific security properties in order to guarantee user’s privacy is a living matter. On the other hand, high-throughput systems in genomics (e.g. the so-called Next Generation ... -
Synthesis, characterization and cytotoxicity studies of novel organo-metallic compounds
(Universita degli studi di Salerno, 2015-04-24)Despite the discovery of cis-platin in the treatment of cancer there has been a considerable exploration on the antitumoral activity of other transition metal complexes. One of the main problems about the application ... -
L'influenza del rame sull'espressione e l'attività del fattore gastrointestinaleTFF1
(Universita degli studi di Salerno, 2015-04-23)Il tratto gastrointestinale rappresenta una interfaccia tra il corpo e l’ambiente esterno. È dotato di sofisticati meccanismi che ne regolano la funzionalità e attua efficaci strategie per la sua protezione affidandosi a ... -
Studio della biodiversità mediante marcatori molecolari di popolazioni naturali e di ecotipi orticoli della regione Campania
(Universita degli studi di Salerno, 2015-04-20)Il progetto di ricerca oggetto della mia tesi di dottorato intitolata "Studio della Biodiversità Mediante Marcatori molecolari di popolazioni naturali e di ecotipi Orticoli della Regione Campania" è stato focalizzato sulla ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ...
