Area Scienze mediche: Recent submissions
Items 61-80 di 162
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PGI products of Campania region: chemical and biological investigation of edible parts and by-products as potential sources of functional ingredients for herbal, nutraceutical and cosmetic formulations.
(Universita degli studi di Salerno, 2018-05-05)This project is addressed to the definition of the chemical profile of selected PGI products of Campania region and related byproducts to highlight the presence of phytochemicals with health benefits. The species studied ... -
Chemical and biological study of natural substances active on the central nervous system
(Universita degli studi di Salerno, 2018-04-05)The research project "Chemical and biological study of natural substances active on the Central Nervous System" has been focused on the possible effects of essential oils, their main constituents (in particular monoterpenes), ... -
Design, synthesis and biological activity of new target selective antitumoral agents
(Universita degli studi di Salerno, 2018-04-05)Cancer development is a complex pathological process that exploits a variety of biological actors. The identification of new molecular entities able to interfere with new biological targets, involved in tumorigenesis, is ... -
Design, synthesis and biological evaluation of new small-molecule modulators of proein lysine methyltransferases (PKMTs)
(Universita degli studi di Salerno, 2018-04-20)Histone lysine methyltransferases have crucial roles in a number of biological processes and human diseases by controlling gene expression and chromatin state. Within this family, the lysine methyltransferase G9a has emerged ... -
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)The normal heart rhythm is guaranteed by an important intercellular junctions system, named Gap Junction (GJs). Each GJs consists of two units called connexons formed by six specific trans-membrane proteins named connexins ... -
Computational design of new antimicrobial peptides
(Universita degli studi di Salerno, 2018-04-13)Antimicrobial peptides (AMP) are evolutionarily conserved components of the innate immune system. They have a broad spectrum of action against bacteria, fungi and viruses. Therefore, AMP are studied as probable substitutes ... -
Drug delivery to the lung in Cystic Fibrosis: deposition, dissolution, mucus interaction and microbiological evaluation of dry powder inhalers
(Universita degli studi di Salerno, 2018-04-05)The inhalation therapy consists of a direct administration of drugs for the treatment of lung diseases. A formulation for inhalation is a valid option in the symptomatic management of pulmonary diseases typical of cystic ... -
Metabolic control of FoxP3 expression in human regulatory T cells
(Universita degli studi di Salerno, 2017-05-30)Regulatory CD4+CD25+ T (Treg) cells play a central role in the maintenance of immune self-tolerance and homeostasis. Although Treg cells operate through multiple mechanisms, it appears that the expression of the transcription ... -
In vitro effects of bioactive extracts of local Italian cultivars: from molecular mechanisms to potential nutraceutical applications for consumers’ well-being
(Universita degli studi di Salerno, 2017-03-31)Phytochemicals are non-nutritional compounds, naturally present in food and beverages, which exert beneficial effects on human health. The present Doctorate Thesis evaluates the biological properties of bioactive ... -
Creazione di modelli virtuali 3D da immagini TC e RM per la pianificazione degli interventi chirurgici in Chirurgia Pediatrica
(Universita degli studi di Salerno, 2017-05-23)BACKGROUND. Lo sviluppo di sistemi medicali sempre più avanzati per l’acquisizione delle immagini finalizzati all’estrazione di informazioni tridimensionali sugli organi del corpo umano tramite metodi non invasivi, hanno ... -
Rischio clinico, gestione del rischio e sue implicazioni. Un aspetto della medicina traslazionale
(Universita degli studi di Salerno, 2017-06-05)This thesis is based on the awareness that prevention in the ethical and vocational training of health workers is extremely important, above all the one concerned with the clinical risk as well as a competent and intelligent ... -
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ... -
NMR-based metabolomic analysis of biological fluids to monitor relevant unsolved diseases
(Universita degli studi di Salerno, 2017-03-30)Metabolomics and metabonomics encompass the comprehensive profiling of multiple metabolite concentrations and their cellular and systemic fluctuations in response to drugs, diet, lifestyle, environment, stimuli and genetic ... -
Bioactives from agricultural food by-products: application in food and health
(Universita degli studi di Salerno, 2017-04-04)Agriculture and agri-food industry produce a large amount of residues in non-edible portions from cultivation and processing of crops. These wastes, considered by-products, give serious environment damage, if not properly ... -
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ... -
Studio dei meccanismi molecolari alla base dell’azione dei microRNA in processi patologici
(Universita degli studi di Salerno, 2016-05-10)My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ... -
Design, synthesis, biological studies of new mitochondrial modulators improving neurological deficits in experimental models of Huntington's disease
(Universita degli studi di Salerno, 2017-03-22) -
Techniques of proteomic analysis as tools for studies in biomedical field
(Universita degli studi di Salerno, 2017-03-24)It is known that prenatal exposure to pollutants and particularly heavy metals can have long term damaging consequences on infants, due to their accumulation in-body. Since the 1990s, ten million tonnes of waste have been ... -
In vitro and in vivo study of cannabinoids as modulators of Wnt/β-catenin pathway in human colorectal cancer
(Universita degli studi di Salerno, 2017-03-23)Colorectal cancer (CRC) is the second most common cause of cancer death. Molecular events in CRC has been extensively studied and several data suggest that Wnt/β-catenin signaling deregulation play a pivotal role in ... -
Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents
(Universita degli studi di Salerno, 2017-03-22)One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the ...
