Sfoglia Scienze farmaceutiche per Titolo
Items 30-41 di 41
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New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(Universita degli studi di Salerno, 2016-03-16)The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ... -
NMR study of protein-ligand interaction
(Universita degli studi di Salerno, 2015-03-11)My PhD project was focused on the study of protein-ligands interactions using different NMR techniques. NMR has a long history in drug discovery and hit-to-lead optimization. Compared to many other biophysical techniques, ... -
Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models.
(Universita degli studi di Salerno, 2015-03-18)Direct administration of drugs to the lungs has been used for millennia as a major treatment for a number of diseases. Origin of the inhalation therapies can be found 2000 B.C in India, where people were used to smoke ... -
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(Universita degli studi di Salerno, 2011-10-06)Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple eliche in regioni ... -
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(Universita degli studi di Salerno, 2013-06-06)Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ... -
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ... -
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ... -
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(Universita degli studi di Salerno, 2012-03-21)Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ... -
Study of the mechanism of action of bioactive plants tarpenoids
(Universita degli studi di Salerno, 2016-05-06)Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ... -
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)The design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and ... -
Synthesis, characterization and cytotoxicity studies of novel organo-metallic compounds
(Universita degli studi di Salerno, 2015-04-24)Despite the discovery of cis-platin in the treatment of cancer there has been a considerable exploration on the antitumoral activity of other transition metal complexes. One of the main problems about the application ... -
Techniques of proteomic analysis as tools for studies in biomedical field
(Universita degli studi di Salerno, 2017-03-24)It is known that prenatal exposure to pollutants and particularly heavy metals can have long term damaging consequences on infants, due to their accumulation in-body. Since the 1990s, ten million tonnes of waste have been ...