Sfoglia Scienze farmaceutiche per Titolo
Items 35-41 di 41
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Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ... -
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ... -
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(Universita degli studi di Salerno, 2012-03-21)Mapping of the interaction between STAT1 and flavonoids Abstract An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ... -
Study of the mechanism of action of bioactive plants tarpenoids
(Universita degli studi di Salerno, 2016-05-06)Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ... -
Synthesis of novel ligands for the stabilization of organometallic complexes having potential antitumor activity
(Universita degli studi di Salerno, 2016-05-04)The design of new metal complexes as anticancer agents has received considerable interest in recent years. Complexes of titanium (e.g.: titanocene dichloride), lanthanides complexes (e.g.: texaphyrrins lanthanide) and ... -
Synthesis, characterization and cytotoxicity studies of novel organo-metallic compounds
(Universita degli studi di Salerno, 2015-04-24)Despite the discovery of cis-platin in the treatment of cancer there has been a considerable exploration on the antitumoral activity of other transition metal complexes. One of the main problems about the application ... -
Techniques of proteomic analysis as tools for studies in biomedical field
(Universita degli studi di Salerno, 2017-03-24)It is known that prenatal exposure to pollutants and particularly heavy metals can have long term damaging consequences on infants, due to their accumulation in-body. Since the 1990s, ten million tonnes of waste have been ...