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Design and synthesis of “small molecules” as antiviral and radiotracer agents
(Universita degli studi di Salerno, 2011-03-28)
The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ...
Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases
(Universita degli studi di Salerno, 2011-02-21)
The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ...
Chemical proteomics on ligand protein
(Universita degli studi di Salerno, 2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(Universita degli studi di Salerno, 2011-10-06)
Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado
di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple
eliche in regioni ...
Design and synthesis of new polycyclic compounds with potential anticancer activity
(Universita degli studi di Salerno, 2011-02-21)
p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ...