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Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(Universita degli studi di Salerno, 2012-03-21)
Mapping of the interaction between STAT1 and flavonoids
Abstract
An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ...
Biophysical investigation of biomolecules in bio-membrane models
(Universita degli studi di Salerno, 2012-05-30)
Many drugs are available for the treatment of systemic or superficial mycoses,
but only a limited number of them are effective antifungal drugs, devoid of
toxic and undesirable side effects. Therefore there remains an ...
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(Universita degli studi di Salerno, 2012-03-07)
The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ...
Exploring the chemical diversity in marine organisms: new molecules for pharmaceutical applications
(Universita degli studi di Salerno, 2012-02-23)
It is increasingly recognized that the oceans preserve a huge number of natural products and novel chemical entities, with biological activities that may be useful in the quest for finding drugs with greater efficacy and ...
Design, virtual screening and structural studies of new molecules with potential antitumor and antiinflammatory activity
(Universita degli studi di Salerno, 2012-03-30)
Computational methodologies in combination with experimental techniques as Nuclear Magnetic Resonance (NMR) have become a crucial component in drug discovery process, from hit identification to lead optimization.
The study ...