Browsing Scienza e tecnologie per l’industria chimica, farmaceutica e alimentare by Author "Ciambelli, Paolo"
Now showing items 1-14 of 14
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A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
(Universita degli studi di Salerno, 2013-10-14)Sensitive effect determination, the understanding of molecular toxicity mechanisms and the discovery of novel biochemical biomarkers are some of the major challenges in ecotoxicology in dealing with chemicals in the ... -
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ... -
Development of dosimeters with selective materials to high frequency radiation
(Universita degli studi di Salerno, 2013-01-23)The clinical use of ionizing radiation to obtain a necrosing or cytotoxic radiobiological effect on tumoral lesions requires wide and complex physical and dosimetrical procedures. In particular, it is necessary to calculate ... -
Development of selective materials and methods for analytical techniques combined with mass spectrometry
(Universita degli studi di Salerno, 2015-04-23)Mass spectrometry (MS) is a powerful detection technique that has become very important in several chemical disciplines for detection of both small molecules (environmental pollutants, small metabolites) and large biomolecules ... -
Foam Injection molding with physical blowing agents
(Universita degli studi di Salerno, 2015-04-20)Foam injection molding uses environmental friendly blowing agents under high pressure and temperature to produce parts having a cellular core and a compact solid skin (the so-called “structural foam”). The addition of a ... -
Forest Fire Modelling
(Universita degli studi di Salerno, 2015-04-21)Wildland fires have always been undesired and dangerous events. The danger includes the destruction of a renewable natural resource, damage of the atmospheric environment through the emissions of pollutant gases, which ... -
Improving the aircraft safety by advanced structures and protecting nanofillers
(Universita degli studi di Salerno, 2014-04-24)Inspection and Maintenance are important aspects when considering the availability of aircraft for revenue flights. Modern airframe design is exploiting new exciting developments in materials and structures to construct ... -
In silico and in vitro models in pharmacokinetic studies
(Universita degli studi di Salerno, 2015-04-21)One of the aims of the thesis was to design and realize an in vitro device able to reproduce the gastrointestinal behavior. To reproduce the temperature and pH history an USP apparatus II coupled with a control system was ... -
Innovative processes for the production of new nanocomposite materials by electrospinning technique
(Universita degli studi di Salerno, 2013-03-19)The technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has ... -
Molecular dynamics investigations of drug-cell membrane interactions
(Universita degli studi di Salerno, 2013-04-22)The cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks. The complex dynamic structure of the plasma membrane ... -
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(Universita degli studi di Salerno, 2013-05-14)Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ... -
Novel technologies and process intensification in the production of micro-systems with pharmacological/nutraceutical activity
(Universita degli studi di Salerno, 2015-04-22)Purpose of the PhD thesis was to develop a novel microencapsulation process, designing and building a single-pot semi-continuous bench scale apparatus. The novel process is based on the coupling of two emerging techniques, ... -
Production of micro and nanoparticles of thermolabile compounds using supercritical assisted atomization
(Universita degli studi di Salerno, 2015-04-20)Supercritical Assisted Atomization (SAA) is a very efficient process to micronize several kind of compounds, such as catalysts, polymers and active principles, also for pharmaceutical applications. The process is based on ... -
Supercritical assisted processes for the production of biopolymeric micro and nanocarriers
(Universita degli studi di Salerno, 2015-04-20)This work provides an innovative point of view on obtaining nanoparticles by supercritical fluids. Supercritical fluids have already been exploited in the production and processing of micro or sub-micro particles, but the ...