Browsing Scienza e tecnologie per l’industria chimica, farmaceutica e alimentare by Author "De Tommasi, Nunziatina"
Now showing items 1-5 of 5
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A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
(Universita degli studi di Salerno, 2013-10-14)Sensitive effect determination, the understanding of molecular toxicity mechanisms and the discovery of novel biochemical biomarkers are some of the major challenges in ecotoxicology in dealing with chemicals in the ... -
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ... -
Development of selective materials and methods for analytical techniques combined with mass spectrometry
(Universita degli studi di Salerno, 2015-04-23)Mass spectrometry (MS) is a powerful detection technique that has become very important in several chemical disciplines for detection of both small molecules (environmental pollutants, small metabolites) and large biomolecules ... -
Molecular dynamics investigations of drug-cell membrane interactions
(Universita degli studi di Salerno, 2013-04-22)The cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks. The complex dynamic structure of the plasma membrane ... -
New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(Universita degli studi di Salerno, 2013-05-14)Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...