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New techniques of molecular modelling and structural chemistry for the development of bioactive compounds
(Universita degli studi di Salerno, 2013-05-14)
Computational chemistry represents today a valid and fast tool for the research of new compounds with potential biological activity. The analysis of ligand-macromolecule interactions and the evaluation of possible “binding ...
A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
(Universita degli studi di Salerno, 2013-10-14)
In silico study of protein-protein interactions
(Universita degli studi di Salerno, 2013-01-30)
Protein-protein interactions are at the basis of many of the most important
molecular processes in the cell, which explains the constantly growing interest
within the scientific community for the structural characterization ...
Development of dosimeters with selective materials to high frequency radiation
(Universita degli studi di Salerno, 2013-01-23)
The clinical use of ionizing radiation to obtain a necrosing or cytotoxic radiobiological effect on tumoral lesions requires wide and complex physical and dosimetrical procedures. In particular, it is necessary to calculate ...
Innovative processes for the production of new nanocomposite materials by electrospinning technique
(Universita degli studi di Salerno, 2013-03-19)
The technical parameters for electrospinning solutions of biodegradable polymers poly(ε-caprolactone), poly(lactic acid) and their composites with active molecules were defined and set up. A trial-and-error approach has ...
Molecular dynamics investigations of drug-cell membrane interactions
(Universita degli studi di Salerno, 2013-04-22)
The cell membrane functions as a platform for the assembly of many signal transduction pathways and provides an additional level of regulation in cell signaling networks.
The complex dynamic structure of the plasma membrane ...
Stereoselective carbon-carbon and carbon-heteroatom bond formation mediated by bifunctional organocatalysts
(Universita degli studi di Salerno, 2013-01-30)
This PhD work describes the development of different Michael and Michael type processes employing different bifunctional organocatalysts. All the processes studied involved a non-covalent activation of the substrates ...
Design, synthesis and biological evaluation of new non-nucleosidic inhibitors od DNA methyltransferases
(Universita degli studi di Salerno, 2013-04-03)
The inactivation of tumor suppressor genes, which often results from epigenetic silencing associated with DNA hypermethylation, plays a pivotal role in the development of most forms of human cancer. Moreover, there are ...
Congegni Supramolecolari basati sul Threading di Calixareni
(Universita degli studi di Salerno, 2013-02-01)
Recently, Neri et al have introduced an efficient method to obtain endo-cavity
complexation and through-the-annulus threading of large calixarenes exploiting the
inducing effect of a weakly coordinating anion, tetrakis ...