http://elea.unisa.it/xmlui/handle/10556/519 Mon, 20 Apr 2026 15:24:10 GMT 2026-04-20T15:24:10Z http://elea.unisa.it/xmlui/handle/10556/630 Title: Letter to the editor: The Use of Organs from Executed Prisoners in China Authors: Romano, Rosalba; Piazza, Ornella Sun, 01 Jan 2012 00:00:00 GMT http://elea.unisa.it/xmlui/handle/10556/630 2012-01-01T00:00:00Z http://elea.unisa.it/xmlui/handle/10556/629 Title: Exercise training in aging and diseases Authors: Conti, Valeria; Russomanno, Giusy; Corbi, Graziamaria; Filippelli, Amelia Abstract: Sedentary lifestyle along with high blood pressure, abnormal values for blood lipids, smoking, and obesity are recognized risk factors for cardiovascular diseases and for many other chronic diseases, such as diabetes, osteoporosis, breast and colon cancer. Several studies conducted on large cohort of individuals have documented the protective effects of physical activity for both vascular and nonvascular syndromes. Exercise training is an integral part of cardiac rehabilitation, a complex therapeutic approach, effective both in young and elderly patients. Despite the number of evidences underling the benefits associated with physical fitness, the cardiac rehabilitation is still an underused medical resource. The molecular mechanism behind physical activity protective effect is presently unresolved, and further studies are also needed to establish the best protocol in terms of specificity, volume and duration of the training. Sun, 01 Jan 2012 00:00:00 GMT http://elea.unisa.it/xmlui/handle/10556/629 2012-01-01T00:00:00Z http://elea.unisa.it/xmlui/handle/10556/628 Title: Posttranscriptional gene regulation: novel pathways for glucocorticoids? Anti-inflammatory action Authors: Stellato, Cristiana Abstract: Posttranscriptional gene regulation (PTR) is a fundamental biological process that integrates with the master transcriptional control of gene expression, in ways that only in the last decade have been increasingly understood [1, 2]. While epigenetic and transcriptional events shape cell response qualitatively, deciding the pattern of gene expression to ‘switch on or off’ in response to endogenous or environmental triggers, the key task of PTR is to act as a ‘rheostat’ and rapidly adapt the cellular response by providing the appropriate amplitude and timing to the protein expression patterns [3, 4]. The pivotal role of this mechanism comes to the forefront in inflammatory and immune response, where the changes in amplitude and duration in the expression of dangerous and protective genes are in delicate balance, and are critical in determining either the successful resolution of the immune response or its chronic overexpression [5]. This brief review introduces members of the main classes of molecules mediating the cytoplasmic arm of gene regulation, namely RNAbinding proteins and micro-RNA (miRNA), and summarizes experimental data that underscore the role of these molecules in the pathophysiology of chronic inflammation, as well as their promising value as mechanisms conveying the anti-inflammatory effect of synthetic glucocorticoids. Sun, 01 Jan 2012 00:00:00 GMT http://elea.unisa.it/xmlui/handle/10556/628 2012-01-01T00:00:00Z http://elea.unisa.it/xmlui/handle/10556/627 Title: Breakthrough pain: the importance of baseline analgesic regimen with opioids Authors: Zampi, Maddalena; Morabito, Antonietta; Salvato, Fabiana; Vinciguerra, Annamaria Abstract: Pain is one of the most common and often most feared symptoms in patients with cancer. Ongoing or progressive pain is physically debilitating and has a marked impact on quality of life. During their illness, at least 70% of patients will experience pain sufficiently severe to require chronic opioid treatment. Moreover, Breakthrough Pain (BTP) consists in transitory exacerbations of pain that occurs on a background of otherwise stable pain in a patient receiving chronic opioid therapy. An inadequate baseline therapy with opioids can be one of the causes of BTP. We will examine the molecular issues that influence the response of patients to opioids. Finally, we will discuss about the importance of individualizing therapy. Sun, 01 Jan 2012 00:00:00 GMT http://elea.unisa.it/xmlui/handle/10556/627 2012-01-01T00:00:00Z