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dc.contributor.authorMarzetti, E.-
dc.contributor.authorCalvani, R.-
dc.contributor.authorCesari, M.-
dc.contributor.authorTosato, M.-
dc.contributor.authorCherubini, A.-
dc.contributor.authorDi Bari, M.-
dc.contributor.authorPahor, M.-
dc.contributor.authorSavera, G.-
dc.contributor.authorCollamati, A.-
dc.contributor.authorD'Angelo, E.-
dc.contributor.authorBernabei, R.-
dc.contributor.authorLandi, F.-
dc.date.accessioned2019-11-07T14:38:12Z-
dc.date.available2019-11-07T14:38:12Z-
dc.date.issued2015-
dc.identifier.citationMarzetti E, Calvani R, Cesari M, Tosato M, Cherubini A, Di Bari M , Pahor M, Savera G, Collamati A, D'Angelo E, Bernabei R, Landi F. Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation. Translational Medicine @ UniSa 2015, 13(5): 29-32it_IT
dc.identifier.issn2239-9747it_IT
dc.identifier.urihttp://elea.unisa.it:8080/xmlui/handle/10556/3782-
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-2004-
dc.description.abstractOver the years, different operational definitions have been elaborated to identify frail older persons, but none of them has received unanimous consensus. This, in turn, has hampered the clinical implementation of frailty as well as the design of targeted interventions. To overcome the current limitations in the field, a novel operationalization of physical frailty (PF) is proposed which grounds its roots in the recognition of sarcopenia as its central biological substrate. This conceptualization is based on the fact that the clinical picture of PF overlaps substantially with that of sarcopenia. The two conditions may therefore be merged into a new clinical entity, the PF & sarcopenia (PF&S) syndrome, in which muscle loss represents both the biological substrate for the development of PF and a major pathway whereby the negative health outcomes of PF occur. All of the components defining the PF&S syndrome are measurable in an objective manner, which will facilitate its incorporation into standard practice. The recognition of a precise biological substratum for PF&S (i.e., skeletal muscle decline) also opens new venues for the development of preventive and therapeutic interventions.it_IT
dc.format.extentP. 29-32it_IT
dc.language.isoenit_IT
dc.sourceUniSa. Sistema Bibliotecario di Ateneoit_IT
dc.subjectAgingit_IT
dc.subjectPhysical performanceit_IT
dc.subjectPunctional impairmentit_IT
dc.subjectSkeletal muscleit_IT
dc.subjectDisabilityit_IT
dc.subjectOrgan failureit_IT
dc.titleOperationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementationit_IT
dc.typeJournal Articleit_IT
È visualizzato nelle collezioni:Translational Medicine @ UniSa. Volume 13 (sept.-dec. 2015)

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