Sfoglia per Soggetto "Cancer"
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Advanced applications of robotics in digestive surgery
(2011)Laparoscopy is widely recognized as feasible and safe approach to many oncologic and benign digestive conditions and is associated with an improved early outcome. Robotic surgery promises to overcome intrinsic limitations ... -
Design and synthesis of new polycyclic compounds with potential anticancer activity
(Universita degli studi di Salerno, 2011-02-21)p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ... -
Design, synthesis and biological evaluation of small molecules able to interact with macromolecular targets involved in tumor pathology
(Universita degli studi di Salerno, 2021-05-06)Inflammation and cancer are two complex pathological processes that exploit several molecular actors. The identification of new platforms able to interfere with biological targets placed at the crossroads of these two ... -
Dual role of grk5 in cancer development and progression
(2016)GRK5 is a multifunctional protein that is able to move within the cell in response to various stimuli to regulate key intracellular signaling from receptor activation, on plasmamembrane, to gene transcription, in the ... -
Role of CD73 - A2A/A2B receptors axis in cancer
(Universita degli studi di Salerno, 2018-04-05)The adenosinergic pathway plays a critical role in cancer development and progression, as well as in drug resistance to chemotherapy and/or targeted-therapy. The goal of this PhD thesis was to investigate and fully ... -
Structural studies, design, identification and biological evaluation of bioactive compounds settore
(Universita degli studi di Salerno, 2016-04-04)Computational methodologies in combination with experimental biological assay represent fundamental key tools in the drug discovery process. The study of ligand-macromolecule interactions has a crucial role for the design, ... -
To NFkB or not to NFkB: the dilemma on how to inhibit a cancer cell fate regulator
(2012)Nuclear factor B (NFB) is a transcription factor that plays an important role in carcinogenesis as well as in the regulation of inflammatory response. NFB is constitutively expressed in tumours where it induces ...
