| dc.contributor.author | Cascone, Sara | |
| dc.contributor.author | Lamberti, Gaetano | |
| dc.contributor.author | Titomanlio, Giuseppe | |
| dc.date.accessioned | 2015-01-29T11:34:13Z | |
| dc.date.available | 2015-01-29T11:34:13Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Cascone S, Lamberti G, Titomanlio G. Designing in-vitro systems to simulate the in-vivo permeability of drugs. Translational Medicine @ UniSa 2014;10(5):14-21 | |
| dc.identifier.issn | 2239-9747 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10556/1636 | |
| dc.identifier.uri | http://dx.doi.org/10.14273/unisa-440 | |
| dc.description.abstract | In this work an engineering approach,
consisting in an experimental procedure and a model to
derive the data, was presented and applied to improve the
testing methods of pharmaceuticals. The permeability of
several active molecules have been evaluated across a
synthetic membrane. The permeability of these drugs
measured through the artificial membrane were successfully
correlated to their in-vivo permeability. The relationship
with in-vivo permeability was derived, and then a rule to
design systems to simulate the intestinal absorption was
proposed to reduce the need for expensive and ethical
problematic in-vivo measurements | en_US |
| dc.format.extent | P. 14-21 | en_US |
| dc.language.iso | en | en_US |
| dc.source | UniSa. Sistema Bibliotecario di Ateneo | en_US |
| dc.subject | Permeability | en_US |
| dc.subject | Artificial membranes | en_US |
| dc.subject | Franz cell | en_US |
| dc.subject | In-vitro/in-vivo correlations | en_US |
| dc.subject | Stokes radius | en_US |
| dc.subject | Oral delivery | en_US |
| dc.title | Designing in-vitro systems to simulate the in-vivo permeability of drugs | en_US |
| dc.type | Article | en_US |
