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dc.contributor.authorCascone, Sara
dc.contributor.authorLamberti, Gaetano
dc.contributor.authorTitomanlio, Giuseppe
dc.date.accessioned2015-01-29T11:34:13Z
dc.date.available2015-01-29T11:34:13Z
dc.date.issued2014
dc.identifier.citationCascone S, Lamberti G, Titomanlio G. Designing in-vitro systems to simulate the in-vivo permeability of drugs. Translational Medicine @ UniSa 2014;10(5):14-21
dc.identifier.issn2239-9747en_US
dc.identifier.urihttp://hdl.handle.net/10556/1636
dc.identifier.urihttp://dx.doi.org/10.14273/unisa-440
dc.description.abstractIn this work an engineering approach, consisting in an experimental procedure and a model to derive the data, was presented and applied to improve the testing methods of pharmaceuticals. The permeability of several active molecules have been evaluated across a synthetic membrane. The permeability of these drugs measured through the artificial membrane were successfully correlated to their in-vivo permeability. The relationship with in-vivo permeability was derived, and then a rule to design systems to simulate the intestinal absorption was proposed to reduce the need for expensive and ethical problematic in-vivo measurementsen_US
dc.format.extentP. 14-21en_US
dc.language.isoenen_US
dc.sourceUniSa. Sistema Bibliotecario di Ateneoen_US
dc.subjectPermeabilityen_US
dc.subjectArtificial membranesen_US
dc.subjectFranz cellen_US
dc.subjectIn-vitro/in-vivo correlationsen_US
dc.subjectStokes radiusen_US
dc.subjectOral deliveryen_US
dc.titleDesigning in-vitro systems to simulate the in-vivo permeability of drugsen_US
dc.typeArticleen_US
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