Modulators of protein-protein interactions with anticancer activity

Abstract

The identification of small molecules targeting specific protein-protein interactions (PPIs) involved in the regulation of the cell cycle is a recent and promising approach for the development of new anticancer agents. Targeting PPIs has long been viewed as a very challenging task because protein-protein interfaces tend to be large and flat. However, the discovery of so-called “hot spots” supported the hypothesis that many PPIs are “druggable” by small molecules. This PhD thesis describes the development of new modulators of the p53/MDM2/MDM4 interaction, and new microtubules targeting agents... [edited by Author]