Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro. L'ambiente ipossico del tumore stimola ...

Serum profile, in physiological or pathological conditions, results from the whole effect of both nutritional intake and endogenous metabolism and is commonly used as diagnostic tool. Moreover individual serum components ...

The maintenance of gastrointestinal tissue integrity is physiologically essential in the presence of the persistent harassment of microbial flora and injurious agents. Even though the repair of the gastric epithelium may ...

The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful ...

Molteplici analisi in vitro e in vivo hanno evidenziato la capacità di diversi fattori nutrizionali di influenzare i processi di carcinogenesi e di progressione tumorale. Gli acidi grassi polinsaturi (PUFA) della serie ...

Nell’ambito del progetto di ricerca dal titolo “Valutazione dell’induzione di risposta adattativa a mutageni in colture cellulari di mammifero in seguito ad esposizioni a campi elettromagnetici non ionizzanti” è stato ...

BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating ...

My research project concerns the study of the molecular mechanisms involving microRNAs (miRNAs) in pathological processes such as tumors and cardiovascular diseases. miRNAs are small non-coding RNAs (sncRNAs) acting by ...

Phytocannabinoids, the major secondary metabolites of cannabis plants, exert a wide range of biological activities. The present work was focused on investigating the mechanism of action of cannabidiolic acid (CBDA) in U87MG ...

Celiac disease (CD) is a life-long gluten-sensitive immune-mediated disorder that primarily affects the small intestine of genetically susceptible individuals worldwide. Type 2 transglutaminase (TG2) has two crucial roles ...