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Neurodegeneration in Chronic Kidney Disease: role of neuroinflammation and uremic toxins
(Universita degli studi di Salerno, 2017-03-28)
Neuroinflammation and oxidative stress have been recognized as common aspects in neurodegenerative diseases. Although the inflammatory process may induce beneficial effects, such as the elimination of the pathogen, ...
Antioxidative and antisenescent effects of cardiac rehabilitation in heart failure patients
(Universita degli studi di Salerno, 2016-04-26)
Exercise-based cardiac rehabilitation (CR) is effectively used as an adjuvant therapy in a number of cardiovascular diseases (CVDs), including chronic heart failure (CHF), and it is recommended by the American and European ...
Role of TFF1 in tumor progression
(Universita degli studi di Salerno, 2017-03-31)
Trefoil Factor 1 (TFF1) is a small secreted protein, belonging to the trefoil factor family, characterized by a conserved “trefoil domain” containing six cysteine residues that form a three loop disulphide structure. It ...
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(Universita degli studi di Salerno, 2017-03-28)
Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ...
Trattamento delle fratture blow-out dell’orbita: endoscopia versus chirurgia tradizionale
(Universita degli studi di Salerno, 2016-05-04)
In the last decades, diagnostical imaging, surgical techniques, alloplastic materials,
and surgical instruments development, allowed a great progress in management of
orbital fractures. The aim of the present study was ...
Role of Annexin A1 in tumor progression
(Universita degli studi di Salerno, 2016-10-06)
Annexin 1 (ANXA1) is a multifunctional protein of 37 kDa, and represents the first characterized member of the annexin superfamily, so called since their main property is to bind (i.e. to annex) cell membranes in Ca2+-dependent ...
Molecular basis of cardiomiopathy
(Universita degli studi di Salerno, 2018-04-05)
The normal heart rhythm is guaranteed by an important
intercellular junctions system, named Gap Junction (GJs). Each
GJs consists of two units called connexons formed by six
specific trans-membrane proteins named connexins ...
Il sistema adenosinico: principali targets molecolari ad attività anti-tumorale
(Universita degli studi di Salerno, 2012-02-27)
L’Adenosina (Ado) è una molecola segnale di origine purinica che esplica le sue funzioni
metaboliche mediante quattro recettori metabotropici (A1, A2A, A2B, A3). L’Ado è un
autacoide ad attività pleiotropica, che regola ...
Ruolo dell'annessina A1 nel processo di differenziamento muscolare
(Universita degli studi di Salerno, 2011-02-21)
Annessina A1 (ANXA1, lipocortina 1) è il primo membro caratterizzato della superfamiglia delle annessine, proteine così chiamate per la loro proprietà di legare (to annex) le membrane cellulari in maniera Ca2+-dipendente.
ANXA1 ...
Le complicanze cardiovascolari nel diabete mellito: studio delle basi molecolari
(Universita degli studi di Salerno, 2013-02-13)
Diabetes is characterized by development of specific microvascular complications and by a high incidence of accelerated atherosclerosis.
The assumption underlying current clinical treatment is that lowering the level of ...