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A chemical-toxicological study of animal models exposed to organohalogen environmental contaminants
(2013-10-14)
Sensitive effect determination, the understanding of molecular toxicity mechanisms and the
discovery of novel biochemical biomarkers are some of the major challenges in ecotoxicology in
dealing with chemicals in the ...
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(2012-03-07)
The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ...
Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models.
(2015-03-18)
Direct administration of drugs to the lungs has been used for millennia as a major treatment for a number of diseases. Origin of the inhalation therapies can be found 2000 B.C in India, where people were used to smoke ...
New Encapsulation Technologies for The Development of in Situ Gelling Micro- Nano Particulate Systems for The Wound Healing
(2016-03-16)
The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ...
Proteomic profiles of cultured cells stimulated with VEGFs dimers and search for natural compounds angiogenesis inhibitors
(2013-06-06)
Some members of the vascular endothelial growth factor (VEGF) family, such as VEGF and PlGF, and related receptors (KDR and Flt-1) play a key role in the modulation of angiogenesis, both physiological and pathological. For ...
Alginate hydrogels in drug delivery: from physico- chemical to technological studies of a promising polysaccharide for 3D printing applications.
(2022-10-20)
Focusing the attention on the futuristic concept of personalized medicine, the Ph.D. project aimed to
demonstrate the potentialities of hydrogels as a versatile feed material for the semi solid extrusion 3D
printing process ...
Innovative technological strategies for the production of in situ gelling powders containing active biomolecules for wound healing
(2022-05-02)
The aim of this Ph.D. project is the development of novel topical formulations for the treatment of
various wounds by innovative technologies (micro and nano spray drying). The specific objective is
the production of a dry ...
Design and production of personalised medicines via innovative 3D printing technologies
(2021-05-04)
The perspective of personalized therapies in recent years is projecting the community towards a rampant hankering for individualization of healthcare.
Paramount is the necessity of re-organizing the healthcare services and ...
Chronotherapeutic Drug Delivery in Early Morning Pathologies: Design and Production of new NSAIDs/SAIDs polysaccharide-based systems
(2017-03-28)
The major technological challenge encountered when formulating new dosage forms is to find a way to adapt drug release kinetics to specific clinical requirements, with the aim to enhance the therapeutic action of both new ...
Study of the mechanism of action of bioactive plants tarpenoids
(2016-05-06)
Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ...