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Supramolecular Scaffolds for Biomimetic Catalysis
(Universita degli studi di Salerno, 2018-03-02)
This PhD thesis is concerned with the design, synthesis and the characterization of supramolecular scaffolds for biomimetic catalysis. Development of new organocatalytic systems based upon well-designed calix[4]arene ...
Development of new in vitro models based on the use of electrospun scaffolds and their imaging by multiphoton microscopy coupled with fluorescence lifetime imaging microscopy
(Universita degli studi di Salerno, 2018-02-22)
In this thesis, new possible applications of electrospun scaffolds are presented. Besides, the interaction of human dermal fibroblasts (HDFs) with the materials has been investigated using multiphoton microscopy (MPM) ...
Innovative applications of stable carbon isotope ratio in environmental and food chemistry
(Universita degli studi di Salerno, 2018-03-08)
In the last year, the stable isotope ratio analysis has become a useful tool with many applications in different scientific area. In particular the characteristic isotope signature of materials has permitted to identify ...
Calixarene based catalytic systems
(Universita degli studi di Salerno, 2018-02-22)
Catalysis is the essence of chemistry as it provides useful tools to make and brake chemical bonds. As nature has been a guide to many scientists, it’s no surprise that in the field of catalysis enzymes were a source of ...
Novel macrocyclic systems in asymmetric phase-transfer catalysis
(Universita degli studi di Salerno, 2017-02-27)
In the great realm of organic synthesis, phase-transfer catalysis (PTC) is a well recognized methodology which plays a key role both in industry and academia research. This process involves reactions that take place between ...
Synthesis and properties of linear and cyclic peptoids
(Universita degli studi di Salerno, 2012-03-26)
Le strutture e le attività metaboliche di tutte le cellule si basano su una vasta gamma di molecole comprendenti: amminoacidi, carboidrati, lipidi e nucleotidi, insieme alle forme polimeriche di questi composti. Ognuna di ...
Enzymatic synthesis of macrolactones
(Universita degli studi di Salerno, 2011-02-24)
Macrolactones are a large and structurally diverse class of compounds. Natural products having a
macrolactone structure have been isolated from many natural sources such as plants, insects,
marine organism and bacteria. ...
Design e sintesi di analoghi delle azumammidi, potenti inibitori degli enzimi HDACs
(Universita degli studi di Salerno, 2011-03-07)
Le azumammidi sono cinque ciclopeptidi di origine marina, isolate nel 2003 da
Fusetani et al dalla spugna Mycale izuensis e brevettate dalla Yamanouchi Pharmaceutical.
L'interesse destato da questi metaboliti secondari ...
Chemical proteomics on ligand protein
(Universita degli studi di Salerno, 2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(Universita degli studi di Salerno, 2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...