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New perspectives in phase transfer catalysis
(Universita degli studi di Salerno, 2020-02-11)
The increasing demand for the stereoselective synthesis of bioactive compounds in both industrial and academic research has led to the rapid development of a variety of diastereo- and enantio-selective processes using phase ...
Heterocyclic architecture for the synthesis of anti-HIV protease and anti-cancer compounds
(Universita degli studi di Salerno, 2020-02-14)
Introduction of heterocycle moieties in a bioactive molecule can have important effects on physicochemical and pharmacological properties, because of their chemical stability, their structural rigidity and due to the ...
Chiral Bioactive Cyclopeptoids: Concepts and Purposes
(Universita degli studi di Salerno, 2020-02-09)
Peptides are an endless source of inspiration for medicinal chemistry, as these biomacromolecules regulate a number of biological activities, acting as hormones, neurotransmitters, signalling molecules and so on. They show ...
Interactome analysis of bioactive molecules: optimization of a functional proteomics platform
(Universita degli studi di Salerno, 2020-10-24)
The identification of natural products (NPs) target proteins is pivotal to understand their
mechanism of action, in order to develop molecular probes and/or potential drugs. In the last 15 years,
affinity chromatogra ...
Stereoselectivity in asymmetric processes and molecular assemblies
(Universita degli studi di Salerno, 2020-02-19)
The aim of this thesis was to explore different areas of organic chemistry in which the
stereocontrol in the design of chemical processes and/or molecular assemblies is necessary.
Therefore, the stereoselectivity in ...