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Isolation, characterization and biologica! evaiuation of bioactive compounds from compiex matrices with high nutraceutica! vaiue
(2021-06-17)
My PhD project based its main objective on the isolation, the characterization and the biological evaluation of bioactive compounds deriving from food matrices of animal and vegetable origin typical of the Mediterranean ...
Onconutraceutics and personalized medicine: isolation, characterization, pharmacokinetics and biological evaluation of antiproliferative compounds from complex natural matrices
(2021-06-06)
The PhD research project aims to the study of novel onconutraceuticals obtained from natural matrices for their potential use in the prevention and as valid support to the pharmacological therapies for the treatment of ...
Development of analytical strategies for phytochemical investigation of «superfoods», with particular attention to Botanicals.
(2022-04-27)
There is a great attention to functional foods exerting health benefits. In this frame the claim ‘superfood’ to
characterize products with high nutritional value and bioactive phytochemicals is more and more used. In ...
Design and synthesis of small molecules as ion channel modulators
(2022-05-02)
My PhD research plan relates the exploration of the structural requirements for ionic channels
modulation such as TRPM8 and Kv7 receptors.
About the first field, we prepared a series of tryptophan-based derivatives of our ...
Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(2021-06-25)
Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...
Design, Synthesis, and characterization of peptides from Gp36 FIV glycoprotein
(2022-04-26)
Le glicoproteine gp36 in FIV e gp41 nel virus dell'immunodeficienza umana (HIV) promuovono
la fusione dell'involucro del virus con le membrane delle cellule ospiti. Hanno una struttura simile
che include il peptide di ...
Development of Innovative Agents for the Treatment of Metabolic Diseases
(2022-05-10)
Elevated LDL cholesterol (LDL-C) is an established risk factor in cardiovascular disease, the
leading cause of death in the world. To date three main therapeutic strategies have been evaluated to
reduce circulating LDL-C ...
Development and application of omics technologies for the monitoring of personalized therapeutic protocols
(2022-05-05)
During the 1st year the scientific activity was focused on the development of an experimental protocol
aimed to evaluate the possible involvement of Sortilin (Sort), a membrane glycoprotein, in the
modulation of sphingolipids ...
Design, synthesis and pharmacological evaluation of new enzyme inhibitors
(2023-04-13)
My PhD research plan relates to the exploration of the structural requirements for the modulation
of enzymes involved in the pathogenesis of viral infections and inflammatory disorders. The first part
of my doctoral project ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...