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Rational design, synthesis and in vitro evaluation of cell-active chemical probes for bromodomain-containing proteins Alessandra
(2021-06-25)
Bromodomains (BRDs) are epigenetic readers able to selectively recognize the acetylated lysine residues on histone and non-histone proteins. Through their activity, bromodomain-containing proteins (BRDs) are involved in a ...
Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs (Protein Arginine Methyltransferases)
(2022-05-03)
La metilazione dei residui di arginina è una modifica post-traduzionale molto diffusa, eseguita da una
famiglia di nove metiltransferasi note come PRMT (Protein Arginine Methyltransferases). La
metilazione dell'arginina ...