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Design and synthesis of new polycyclic compounds with potential anticancer activity
(2011-02-21)
p53 is best known as a tumor suppressor that transcriptionally regulates, in response to cellular stresses such as DNA damage or oncogene activation, the expression of various target genes that mediate cell-cycle arrest, ...
Design, synthesis and pharmacological studies of structural analogues modeled on bioactive natural products
(2011-03-21)
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the enzyme responsible for the conversion of the cyclooxygenase (COX)-derived prostaglandins (PG)H2 into PGE2. This enzyme is deeply involved in different pathologies; ...
Design, synthesis and biological evaluation of new small molecule modulators of Arginine methyltransferases
(2011-02-21)
The methylation of arginine residues is a prevalent post-translational modification, found on both nuclear and cytoplasmic proteins, catalyzed by the protein arginine N-methyltransferase (PRMT) family of enzymes. To date ...
Chemical proteomics on ligand protein
(2011-03-18)
The emerging field of mass spectrometry-based chemical proteomics provides a powerful instrument in the target discovery of bioactive small-molecules, such as drugs or natural products[1]. The identification of their ...
Design and synthesis of “small molecules” as antiviral and radiotracer agents
(2011-03-28)
The present Ph.D. project was divided into different work parts, in a way that helps to understand and define the goals of this project. In particular: I) Design, synthesis and evaluation of antiviral activity of Arbidol ...
Physico-chemical characterization of DNA G-quadruplexes and their interaction with proteins and potential anticancer agents
(2011-10-06)
Negli ultimi anni è stato dimostrato che sequenze di DNA (o RNA) ricche in guanine sono in grado
di formare una nuova classe di strutture: le quadruple eliche. Importante e' la presenza di quadruple
eliche in regioni ...
Study of bio-molecar interaction: a) Mapping of the interaction between STAT1 and flavonoids; b) Role of PDIA6-BiP complex in the regulation of the unfolded protein response
(2012-03-21)
Mapping of the interaction between STAT1 and flavonoids
Abstract
An experimental approach is described, in the first part of this Ph.D. work, for determining protein-small molecule non-covalent ligand binding sites and ...
The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity
(2014-05-21)
The thesis entitled “The design and synthesis of novel N-heterocyclic compounds, and their evaluation of anti-cancer and anti-viral activity" is divided into three chapters.
The title of the thesis clearly reflects the ...
Biophysical investigation of biomolecules in bio-membrane models
(2012-05-30)
Many drugs are available for the treatment of systemic or superficial mycoses,
but only a limited number of them are effective antifungal drugs, devoid of
toxic and undesirable side effects. Therefore there remains an ...
Design and characterization of DPI (dry powder inhaler) for the pulmonary delivery of anti-inflammatory and antibiotic drugs in the treatment of cystic fibrosis disease
(2012-03-07)
The aim of the present PhD project was to design inhalable powder-based formulations for pharmaceutical products that may improve the treatment of pulmonary diseases, mainly cystic fibrosis, and may be easier for patients ...