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Now showing items 31-40 of 41
Study of the mechanism of action of bioactive plants tarpenoids
(2016-05-06)
Natural products are small-molecule secondary metabolites displaying considerable structural complexity and “privileged scaffolds”. They are able to bind several endogenous targets eliciting biological effects as chemical ...
Integrated metabolomics approaches for berry fruit used in nutraceutical formulations
(2016-04-13)
The species under investigation during these three years of PhD course were: Fragaria ananassa, Fragaria vesca, Morus alba, Morus nigra and Myrtus communis. All these species are characterized by the production of small ...
Development of analytical methodology for determination of emerging contaminants in enviroment and food
(2015-04-24)
In recent years, fate, occurrence and potential adverse effect of emerging contaminants (ECs) in the environment have received an increased attention by scientific community. The ECs are a broad category of chemicals, ...
In vitro and in cell functional proteomics on natural compounds
(2014-04-24)
Chemical proteomics has acquired a pivotal role in chemical biology because of its peculiar capability to deeply analyze the proteome from many points of view. Proteins identification, characterization and quantification ...
Design, synthesis and biological studies of novel heterocyclic compounds as anticancer drugs
(2015-04-24)
Heterocyles are an essencial class of molecules, assuming a role in many aspect of
our life. Indeed heterocyclic nucleus is a common feature of several biomolecule and
bioactive compounds including agrochemical products ...
Role of the inflammasome in lung cancer Inflammasome is involved in lung carcinogenesis
(2017-03-28)
Lung cancer is recognized as one of the most devastating tumor worldwide due to the low rate survival over 5 years from the time of diagnosis. Inflammation has been widely recognized as the seventh hallmark of cancer as ...
Design and structural optimization of new molecules as potential antiinflammatory and/or anticancer agents
(2015-03-10)
L’infiammazione ed il cancro sono due complessi meccanismi patologici in cui risultano coinvolti una serie di differenti mediatori molecolari. La profonda connessione tra cancro ed infiammazione è ben nota e la modulazione ...
Design and synthesis of peptides that modulate apoptotic process
(2014-11-17)
Oncogenic activation of tyrosine kinases is a common feature in cancer, and its regulation represents an excellent antitumoral target. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). ...
New Encapsulation Technologies for The Development of in Situ Gelling Micro-Nano Particulate Systems for The Wound Healing
(2016-03-16)
The Ph.D project titled “New Encapsulation technologies for the development of in situ gelling micro-nano particulate systems for the wound healing” aimed to develop novel topical formulations by innovative technologies, ...
Novel respirable powder formulation: design, aerosolization and permeation studies through pulmonary epithelial cell line and mucus models
(2015-03-18)
Direct administration of drugs to the lungs has been used for millennia as a major treatment for a number of diseases. Origin of the inhalation therapies can be found 2000 B.C in India, where people were used to smoke ...