Sfoglia Translational Medicine @ UniSa. Vol.8 (jan.-mar. 2014) per Data di Pubblicazione
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Are T-LGL leukemia and NK-chronic lymphoproliferative disorder really two distinct diseases?
(2014)Mature Large Granular lymphocytes (LGL) disorders include a spectrum of conditions, ranging from polyclonal to clonal indolent and/or overt leukemic LGL proliferations. Most cases are represented by clonal expansions of ... -
Clonal non-malignant hematological disorders: unraveling molecular pathogenic mechanisms to develop novel targeted therapeutics
(2014)Clonal non-malignant hematological disorders are a heterogeneous group of diseases that are particularly challenging for hematologists. Indeed, most obvious and frequent hematological diseases include a broad spectrum of ... -
Errata corrige
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Immunological derangement in Hypocellular Myelodysplastic Syndromes
(2014)Hypocellular or hypoplastic myelodysplastic syndromes (HMDS) are a distinct subgroup accounting for 10–15% of all MDS patients, that are characterized by the presence of bone marrow (BM) hypocellularity, various degree of ... -
Molecular Genetics of Myelofibrosis and its associated Disease Phenotypes
(2014)In 2005, the discovery of Janus kinase 2 (JAK2) V617F mutation in approximately half of patients with myelofibrosis (MF) marked an important milestone in our understanding of the pathophysiology of MF. This has broadened ... -
Molecular Pathogenesis of Myelodysplastic Syndromes
(2014)Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in ... -
Anti-complement treatment in paroxysmal nocturnal hemoglobinuria: where we stand and where we are going
(2014)Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, non-malignant, hematological disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ... -
Current Concepts on Diagnosis and Treatment of Mastocytosis
(2014)Mastocytosis is a heterogeneous group of disorders characterized by a clonal proliferation and accumulation of mast cells in one or more organ, primarily in the skin and bone marrow. The clinical spectrum of the disease ... -
Discovering the meaning of monoclonal gammopathy of undetermined significance: current knowledge, future challenges
(2014)Monoclonal gammopathy of undetermined significance (MGUS) is a non malignant plasma cell disorder with a relatively low risk of progression to Multiple Myeloma (MM) and to related Plasma cells disordes (lymphoplasmacellular ... -
Monoclonal B-cell lymphocytosis
(2014)Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 109/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, ...
