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dc.contributor.authorDi Sarno, Veronica
dc.date.accessioned2016-09-26T10:54:16Z
dc.date.available2016-09-26T10:54:16Z
dc.date.issued2016-03-23
dc.identifier.urihttp://hdl.handle.net/10556/2229
dc.description2014 - 2015it_IT
dc.description.abstractp53 is a transcription factor with tumour suppressor properties, which is able to induce mitochondrial apoptosis independently of its transcriptional activity. Analogues of the spiro[imidazo[1,5-c] thiazole-3,3′-indoline] -2′,5,7(6H,7aH) -trione, previously synthesized from my research group, as p53 modulators were synthesized during my PhD, aiming to explore new structural requirements at the thiazolidine domain to increase the antiproliferative activity and improve p53 modulation. Derivative 5-bromo-3′- (cyclohexane carbonyl) -1-methyl-2oxospiro[indoline-3,2′-thiazolidine] (SM13) emerged as the most potent compound of all series, inhibiting, in vitro, 30% of p53−MDM2 interaction at 5 μM and the cell growth of different human tumor cells at nanomolar concentrations... [edited by author]it_IT
dc.language.isoenit_IT
dc.publisherUniversita degli studi di Salernoit_IT
dc.subjectP53it_IT
dc.subjectMDM2it_IT
dc.subjectSM13it_IT
dc.titleDesign and synthesis of modulators of apoptotic activityit_IT
dc.typeDoctoral Thesisit_IT
dc.subject.miurCHIM/08 CHIMICA FARMACEUTICAit_IT
dc.contributor.coordinatoreSbardella, Gianlucait_IT
dc.description.cicloXIV n.s.it_IT
dc.contributor.tutorCampiglia, Pietroit_IT
dc.identifier.DipartimentoFarmaciait_IT
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