Browsing Translational Medicine @ UniSa by Issue Date
Now showing items 1-20 of 284
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End of life in intensive care unit
(2011) -
Emergency contraception: an updated review
(2011)Emergency contraception is a common practice now. Many categories of drugs are marketed with modifications in dosage, in combination and even in the timing of administration. Recent re-analysis suggests that there is still ... -
Adrenergic mechanism in the control of endothelial function
(2011)There is considerable evidence that many disease are associated with endothelial dysfunction and reduced nitric oxide production such as hypertension, obesity, dyslipidemias, diabetes, heart failure, atherosclerosis. Notably ... -
Optical tecnology developments in biomedicine: history, current and future
(2011)Biomedical optics is a rapidly emerging field for medical imaging and diagnostics. This paper reviews several biomedical optical technologies that have been developed and translated for either clinical or pre-clinical ... -
Tracheostomy in spinal cord injured patients
(2011)Patients with cervical spinal cord injury frequently need prolonged mechanical ventilation as a result of worsening pulmonary vital capacity due to paralysis of respiratory muscles, severe impairment of tracheobronchial ... -
Non-immortalized human tenocyte cultures as a vehicle for understanding cellular aspects to tendinopathy
(2011)The biochemical mechanisms underlying tendinopathy are obscure. We briefly describe preliminary observations of human tenocyte behaviour in culture as a vehicle for determining the role of reactive oxygen in tendon pathology -
Autoimmune liver disease: news and perspectives
(2011)Autoimmune liver disorders in childhood include autoimmune hepatitis and autoimmune sclerosing cholangitis. These inflammatory liver disorders are characterised histologically by interface hepatitis, biochemically by ... -
Advanced applications of robotics in digestive surgery
(2011)Laparoscopy is widely recognized as feasible and safe approach to many oncologic and benign digestive conditions and is associated with an improved early outcome. Robotic surgery promises to overcome intrinsic limitations ... -
Potential clinical role of telomere length in human glioblastoma
(2011)Glioblastoma Multiforme (GBM) is the most common and lethal of human primary central nervous system (CNS) tumors. Due to the tumour’s intrinsic clinical and molecular heterogeneity, choice of initial treatment, prediction ... -
Estrogens and neuropeptides in postmenopausal women: un update
(2012)Menopause is characterized by depletion of ovarian follicles, a reduction of ovarian hormones to castrate levels and elevated levels of serum gonadotropins from the anterior pituitary gland. Although this process has ... -
A polymorphism within the promoter of the dopamine receptor D1 (DRD1 -48A7G) associates with impaired kidney function in white hypertensive patients
(2012)Dopamine DRD1 receptor regulates renal function and vascular resistance. It plays a role in the pathogenesis of hypertension in animal models. In humans, the DRD1 gene presents a A-48G polymorphism associated to hypertension ... -
An engineering approach to biomedical sciences: advanced strategies in drug delivery systems production
(2012)Development and optimization of novel production techniques for drug delivery systems are fundamental steps in the “from the bench to the bedside” process which is the base of translational medicine. In particular, in the ... -
1,4-Dihydropyridines: the multiple personalities of a blockbuster drug family
(2012)More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated ... -
An engineering approach to biomedical sciences: advanced testing methods and pharmacokinetic modeling
(2012)In this paper, the philosophy of a research in pharmacology field, driven by an engineering approach, was described along with some case histories and examples. The improvement in the testing methods for pharmaceutical ... -
18F-FDG PET and PET/CT in the localization and characterization of lesions in patients with ovarian cancer
(2012)Aim: The aim was to compare the imaging findings of 18F-fluorodeoxyglucose (18F-FDG) PET and integrated PET/CT in patients with primary, recurrent or metastatic ovarian cancer. Materials and methods. 21 women with ovarian ... -
Transculturality: the new frontier of care relationships
(2012)Taking care of migrants constitutes a new challenge for the actual operative structures of the services in general and for the sanitary service in particular, requiring a global and permanent rethinking with regards to ... -
Prognostic differences between VAP caused by Acinetobacter baumannii and VAP caused by other microorganisms
(2012)Nosocomial infection, in particular pneumonia, is an important risk factor for hospital mortality and morbidity. Acinetobacter baumannii is a common multi-resistant microorganism responsible of Ventilator Associated Pneumonia ... -
Exercise training in aging and diseases
(2012)Sedentary lifestyle along with high blood pressure, abnormal values for blood lipids, smoking, and obesity are recognized risk factors for cardiovascular diseases and for many other chronic diseases, such as diabetes, os ...
