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In vitro apoptotic effects of farnesyltransferase blockade in acute myeloid leukemia cells
(2016)
Farnesyltransferase inhibitors (FTIs)
are a class of oral anti-cancer drugs currently tested
in phase I-II clinical trials for treatment of
hematological malignancies. The in vitro effects of
various FTIs (alpha-hydroxyf ...
67 kDa laminin receptor (67LR) in normal and neoplastic hematopoietic cells: is its targeting a feasible approach?
(2016)
The 67 kDa laminin receptor (67LR)
is a non-integrin cell surface receptor for laminin
(LM) that derives from a 37 kDa precursor (37LRP).
67LR expression is increased in neoplastic cells and
correlates with an enhanced ...
Microvascular blood flow improvement in hyperglycemic obese adult patients by hypocaloric diet
(2016)
The present study was aimed to assess
the changes in skin microvascular blood flow (SBF)
in newly diagnosed hyperglycemic obese subjects,
administered with hypocaloric diet. Adult patients
were recruited and divided in ...
Urokinase type plasminogen activator receptor (uPAR) as a new therapeutic target in cancer
(2016)
The urokinase (uPA)-type
plasminogen activator receptor (uPAR) is a GPIanchored receptor that focuses urokinase (uPA)
proteolytic activity on the cell surface. uPAR also
regulates cell adhesion, migration and proliferati ...
The european innovation partnership on active and healthy ageing synergies: protocol for a prospective observational study to measure the impact of a community-based program on prevention and mitigation of frailty (ICP –PMF) in community-dwelling older adults
(2016)
Aim of this paper is to describe the protocol of the
study “Impact of a Community-based Program on
Prevention and Mitigation of Frailty in communitydwelling older adults” developed in the framework of
the European Innovation ...
Effect of α2-adrenergic agonists and antagonists on cytokine release from human lung macrophages cultured in vitro
(2016)
The most trusted hypothesis to explain
how α2-adrenergic agonists may preserve pulmonary
functions in critically ill patients is that they directly
act on macrophages by interfering with an
autocrine/paracrine adrenergic ...
Use of the directional atherectomy for the treatment of femoro-popliteal lesions in patients with critical lower limb ischemia
(2016)
Femoro-popliteal PTA for the treatment
of critical limb ischemia is frequently associated
with unsatisfactory procedural success rates while
directional atherectomy (DCA) has improved
success rate since claudicant patients ...
Stress-first single photon emission computed myocardial perfusion imaging
(2016)
Background. Myocardial perfusion
imaging (MPI) with single photon emission
tomography (SPET) is widely used in coronary
artery disease evaluation. Recently major
dosimetric concerns have arisen. The aim of this
study was ...
Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment
(2016)
T-large granular lymphocyte
leukemia (T-LGLL) is a chronic clonal proliferation
of effector memory cytotoxic CD3+CD57+CD56- T
cells and the current guidelines suggest
immunosuppressive therapy as first-line therapy, but
the ...
Evaluation of symptoms and prevention of cancer in menopause: the value of vulvar exam
(2016)
Vulvar and vaginal atrophy (VVA), is a chronic medical condition experienced by postmenopausal women, with prevalence estimated ranging from 10% to 50% [1]. VVA is characterized by a
constellation of symptoms, that may ...